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Biocompatibility of thin films based on hydrothermal synthesized HAp

Madalina L. Popescu 2Roxana M. Piticescu 2Stefania Petrescu 4Ion Mihailescu 3Witold Łojkowski 1Robert Fedyk 1

1. Polish Academy of Sciences, High Pressure Research Center (UNIPRESS), Sokolowska 29/37, Warszawa 01-142, Poland
2. Institute for Non-ferrous and Rare Metals, 102 Biruintei Blvd., Pantelimon 73957, Romania
3. National Institute for Lasers Plasma and Radiation Physics (INFLPR), Atomistilor 111, Bucharest -, Romania
4. Institute for Biochemistry of Romanian Academy, Splaiul Independentei, Bucharest, Romania


Implant materials were made from metals such as titanium for a long period of time. Despite its good mechanical properties metals and its alloys may be toxic for the human body.
New materials have been developed for orthopedic implants and artificial teeth. Among these materials, HAp which is known for its high biological activity and its unique property to integrate with bones has attracted attention.
Different techniques for HAp based biomaterials synthesis (mechanical methods,
co-precipitation, biomimetic procedure, hydrothermal procedure) are described in the literature. Hydrothermal synthesis offers many advantages over conventional and non-conventional ceramic synthetic methods. Hydrothermal synthesis is a technology for crystallizing materials (chemical compounds) directly from aqueous solution by adept control of thermodynamic variables (temperature, pressure, composition).
The objective of this paper is to demonstrate the enhanced biocompatibility of HAp thin films starting from hydrothermal synthesized powders.
Hydrothermal synthesized HAp was deposited on pure titanium substrates by PLD at 400oC in water vapor and in oxygen atmosphere, pressure value in the range 3.5 *10-1-10-1 torr. Biocompatibility tests performed on coated titanium showed the ability of the HAp layer to promote cell growth on the surface.


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Presentation: poster at E-MRS Fall Meeting 2004, Symposium I, by Madalina L. Popescu
See On-line Journal of E-MRS Fall Meeting 2004

Submitted: 2004-05-21 09:31
Revised:   2009-06-08 12:55