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Characteristic of hydroxyapatite dense nanoceramic produced by The High Pressure Consolidation  

Elżbieta Pietrzykowska ,  Aleksandra E. Kędzierska ,  Dariusz Smolen ,  Tadeusz Chudoba ,  Witold Łojkowski 

Polish Academy of Sciences, Institute of High Pressure Physics (UNIPRESS), Sokolowska 29/37, Warszawa 01-142, Poland


Regenerative medicine is an emerging multidisciplinary field. The aim is to restore, maintain or enhance tissues and hence organ functions. Nowadays bioactive scaffold is developing. Their’s role is to mimic biological system and initiate the regeneration of tissue in the body. However, currently available materials do not satisfy every clinical application, so there is still a need for new materials which can stimulate the body's own regenerative mechanism and heal tissue.

As it is known bones tissue is consisted of biological systems, which are built up from nanoscale biomolecules. Therefore, nanomaterials can be a key for radical improvement in medicine. The Institute of High Pressure Physics of the Polish Academy of Sciences (IHPP) has  successfully developed the High Pressure Consolidation Technology (HPCT), which gives nanograin size ceramic. The hydroxyapatite nanoceramics produced in IHPP offers great oportunity for obtaining bioactive and resorbable scaffolds.

The HPCT method allows to produce dense ceramic by using extreme high pressure and low temperature. The process conditions are high pressure in range from 4 to 8GPa and  temperature from 24 to 500ºC. This conditions cause the acceleration of the driving force for sintering and reduce pores in the material. Due to this method the nanopowder structure  is maintain. The  nanopowder  structure is significance for material’s bioactivity and resorbability.

The mechanical properties of nanoceramic was investigated. The obtained  material is characterized by 8.3 GPa nanohardness, 124 GPa Young’s Modulus. During the process, the grain size is maintained in the range from 20−40 nm.

These materials are attracting interest in regenerative medicine because of theirs nanostructure which gives good bioactivity,  resorbability and mechanical prosperities.

Acknowledgements: The authors wish to acknowledge the financial support from the project SONOSCA.


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Presentation: Poster at Nano-Biotechnologia PL, by Elżbieta Pietrzykowska
See On-line Journal of Nano-Biotechnologia PL

Submitted: 2012-07-05 13:27
Revised:   2012-08-22 12:05