The aim of the work is to develop new scaffolds for tissue engineering. This supposes to integrate soft chemical methods (hydrothermal and electrochemical methods) for preparing multifunctional biomaterials based on hydroxyl-apatite and functionalized polyurethanes. The innovative part is represented by the following aspects:

- synthesis, in situ under hydrothermal synthesis at low temperatures and high pressures, of new nanostructured hybrid materials with a strong chemical/physical bonding between the components;

-  applying the cyclic voltametry to monitor the electrical response of the nanostructured hybrid thin films deposited by spin-coating on gold-plated silicon wafers used as substrate. Electrochemical measurements were used to monitor cell adhesion, and experiments were designed to determine how various changes in substrates influence the cell adhesion and proliferation. To accomplish these studies, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed. As the cell number increases, the covered surface of electrode with cells will increase and the electrode impedance will change. Depending on the structural and compositional factors of the nanostructured hybrid thin films, the electrical response could be useful in monitoring by electrical simulation of the cell response. The processes at the substrate/hybrid interface have been studied by SEM and HRTEM methods. Biocompatibility studies by in-vitro tests of different immobilized biomolecules are under working.

Acknowledgements: The researches are financially supported by National Authority for Scientific Research in the frame of project 71-004/2007.

References:

1. D.G. Castner, B.D. Ratner, Surface Science, 500 (2002), pp. 28-60
2. G. Kickelbick, Hybrid Materials: Synthesis, Characterization, and Applications, ISBN-13: 978-3-527-31299-3 - Wiley-VCH, Weinheim, 2006
3. M. Wang, Biomaterials 24 (2003), pp. 2133–2151
4. G.K. Knopf, A. S. Bassi, “Smart Biosensor Technology”, CRC Press, 2007

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