Cell elasticity, motility and migration are very important for understanding various biological processes. Currently, monitoring cellular traction forces is desired as new marker to monitor cell functionality. We developed a sensor system for cell force measurement based upon a polymer microchip covered with a micro pillar matrix. The spring constant is chosen to enable pillar bending by forces in the range of 10..100 nN. The pillars bend in response to cellular forces that are transmitted via cellular focal adhesion points. The micro chip is read out optically. Besides a transmission image to analyze pillar bending, two different fluorescence images of dye markers can be taken sequentially. Matrix with the cells is illuminated bys spatially homogenized LED radiation. The focal position during long term experiments can be maintained by means of a piezo stage in order to obtain highly resolved images from the CCD imager. Sophisticated software controls the optical system and performs image registration. First, one transmission (red) as well as two fluorescence images (blue & green) are taken using appropriate CCD gain and integration times. Fluorescence information yields those pillar positions that are at least covered by a cell. The transmission image is used to calculate the magnitude and direction of pillars deflection. Therefore, detection of single pillar position and its deviation from a hexagonal grid is analyzed automatically, enabling a mapping of traction forces.In summary, this system containing transducer polymer chip, optics, and dedicated software analysis is a complete imaging system for image registration, single cell visualization and cellular force measurement. First results of cellular force measurements obtained are presented.

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1. Financing of industry relevant projects in Poland
2. Electrospun nanocomposites from PHBV for bone tissue engineering
3. Nanotechnologie w gospodarce województwa podlaskiego
4. Modeling of growth kinetics of SiC single crystal in PVT process
5. Application of micro- and nanostructured biomaterials in regenerative medicine
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56. Polyurethane nano-composites with luminescence properties for optics and optoelectronics applications.
57. Tailoring mechanical properties by grain refinement and particle redistribution
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59. Surface effect on atomic ordering in nano-layered L1₀ AB binaries: multiscale Monte Carlo Simulation
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62. Influence of hydrostatic extrusion parameters on the microstructure and mechanical properties of 6082 aluminium alloy
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66. Microstructure and mechanical properties of 7475 aluminium alloy processed by SPD methods
67. Investigation of aqueous surface processes and corrosion mechanisms of Al-(Cu)-Fe-Cr quasicrystaline approximant
68. Characterization of the effects of hydrostatic extrusion on structure and surface properties of 303 austenitic stainless steel
69. The Effect of Hydrostatic Extrusion on the Corrosion Stability of Austenitic Stainless Steels
70. The Effect of Hydrostatic Extrusion on Resistance of 316 Austenitic Stainless Steel to Pit Nucleation
71. Nanomaterials in dental applications
72. Nanostructure formation in austenitic stainless steel
73. Evaluation of crystal structure and polytypism of SiC in microwave sintered diamond-SiC composite by TEM and HR-TEM
74. Hydrogen induced changes in 316L stainless steel microstructure
75. Statistical model of grain growth in polycrystalline nanomaterials
76. Repair and regeneration of osteochondral defects in the articular joints
77. Corrosion resistance of nanostructured titanium
78. Effect of surface treatment on the microstructure of TA6V
79. Predicting site occupation of Fe in B2 NiAl from ab initio computations
80. Structure and properties of polyurethane/YAG:Tb³⁺ nano-composites with luminescence properties
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87. Grain Boundary Migration in Nanocrystalline Iron
88. Thermal properties of L1₀-TiAl from first principle calculations
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98. A hybrid atomistic-continuum finite element modelling of locally disordered crystalline structure
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101. The influence of hydrostatic extrusion on mechanical properties and tribological characteristics of an austenitic stainless steel
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142. Professor CZOCHRALSKI - Distinguished Scientist and Inventor, Founder of the Modern Materials Science
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144. Mechanical properties nanostructured iron obtained by different methods of Severe Plastic Deformation
145. Strain localization in nanocrystalline iron after Severe Plastic Deformation
146. Non-elastic behaviours of high-porosity ceramics and ceramic-polymer composites
147. The Superplasticity of Hard Magnetic Alloy Fe-23wt.%Co-30%Cr with Submicrocrystalline Structure
148. Microstructure of Ni-P thin layers obtained by a chemical method
149. Hydrostatic extrusion and nanostructure formation in an aluminium alloy
150. Quantitative Description of Microstructure of Nano-materials
151. The Structure and Mechanical Properties of Low Carbon Low Alloy Steel Subjected to Severe Plastic Deformation
152. Studies of Ni-P Thin Films by Electroles Deposition Method
153. Stereology of Nanomaterials
154. Targeted Research Project: Metallic, Ceramic and Organic Nanomaterials: Processing - Structure - Properties - Applications
155. Materials Research in Poland