Biodegradable and bioabsorbable polymeric - ceramic composites for medical applications

Tomasz Jaroszewicz 1Barbara D. Ostrowska 1Wojciech Swieszkowski 1Miroslawa El Fray 2Krzysztof J. Kurzydlowski 1

1. Warsaw University of Technology, Faculty of Materials Science and Engineering (InMat), Wołoska 141, Warszawa 02-507, Poland
2. Szczecin University of Technology, Polymer Instiute, Pulaskiego 10, Szczecin 70-322, Poland


Bioabsorbable and biodegradable materials are expected to maintain their mechanical properties for an amount of time and then eventually degrade and be resorbed or excreted. Biodegradable polymers, especially those belonging to the family of polyglicolic acid (PGA) and polylactic acid (PLA) together with poly e-caprolactone, play an increasingly important role in medical applications. Due to their properties, they find their place in orthopaedics and tissue engineering. They can be used to manufacture a wide range of bone implants, porous scaffolds and cell carriers for tissue engineering.

Initial durability of polymer made device or the time, when it is suitable, are to small to ensure patient’s full reconvalescence or proper cells density on the scaffold. Therefore, using polymer-ceramic composites as a timber,  besides only polymer or co-polymer made, seem to be more favourable. Ceramics improves implant’s/scaffold’s mechanical properties and vitality which eliminates the risk  of to early disintegration.

The aim of the study was to develop a strong biodegradable implant material which could be used for medical application. Different polymer-ceramic composites were fabricated using combined mixing and extrusion process. PLA, PGA and PCL were selected as a matrix materials. HAp and TCP (10-30%) have been used to reinforce the polymeric matrixes.

Extensive mechanical tests were performed to investigate the mechanical properties of the composite. µCT and nCT as well as SEM, were used to study the ceramic particles distribution in the polymeric matrix. Mechanical tests results show the increase of stiffness, improved tensile and breaking strengths and very low sterilization influence on mechanical properties. The particles were distributed homogeneously in the polymer. The conclusion is that the developed composites may be used as implant materials.

Legal notice
  • Legal notice:

    Copyright (c) Pielaszek Research, all rights reserved.
    The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
    In every case, proper references including Author(s) name(s) and URL of this webpage: must be provided.


Related papers
  1. Financing of industry relevant projects in Poland
  2. Electrospun nanocomposites from PHBV for bone tissue engineering
  3. Nanotechnologie w gospodarce województwa podlaskiego
  4. Modeling of growth kinetics of SiC single crystal in PVT process
  5. Application of micro- and nanostructured biomaterials in regenerative medicine
  6. Core-shell P(LLA-CL) based electrospun nanofibers for peripheral nerve tissue engineering
  7. Surface modification of PCL scaffold changes protein adsorption
  8. TiO2 nanotubes based composite layers for biomedical applications
  9. Synthesis of highly biocompatible hydroxyapatite nanopowders
  10. Modification of epoxy resin properties by adding multi wall carbon nanotubes
  11. Solvothermal synthesis of nonstoichiometric hydroxyapatite nanoparticles
  12. Solvothermal synthesis of nonstoichiometric hydroxyapatite nanoparticles
  13. Możliwości badawcze Laboratorium Skaningowej Mikroskopii Elektronowej na WIM PW
  14. Otwarcie konferencji
  15. Perspektywy rozwoju nanomateriałów konstrukcyjnych i funkcjonalnych
  16. Zastosowania mikroskopii AFM dla farmacji i medycyny
  17. Wykorzystanie nanotechnologii w procesie odlewania precyzyjnego
  18. Oczyszczanie i modyfikacja nanomateriałów węglowych
  19. Modyfikacje polimerów stosowanych w lotnictwie za pomocą nanorurek węglowych
  20. Luminescent polyurethane nanocomposites: processing, structure and properties
  21. Micro Sensor for cell force measurement
  22. Preliminary studies on degradation of polylactides fibers
  23. Effect of grain size on reactive diffusion between Ti-Al
  24. TEM investigations of the nanostructure, multilayer CrN/Cr coatings obtained by vacuum-arc method
  25. Bulk  nanostructured  titanium  fabricated  by  hydrostatic  extrusion
  26. Composites PLLA/MWNTs produced by twin-screw microcompounder
  27. Polyurethane-based material with calcite and aragonite for tissue engineering composite scaffolds
  28.  A  degradable and highly porous polyurethane scaffolds for bone tissue engineering
  29. Reduced activation ODS ferritic steel – recent development in high speed hot extrusion processing
  30. Investigation of the DLC and novel DLC-polymer hybrid coatings using FIB and SEM techniques
  31. A combination of microCT and FEM methods for development of a new scaffold for bone regeneration
  32. Properties of transparent elastomer nanocomposites (polyurethane/ ZrO2:Eu3+) as materials for optoelectronic application
  33. Investigation of fatique crack growth rate of Al 5484 ultrafine grained alloy after ECAP process
  34. Fire retardant polyurethane elastomers/aluminophosphorate nanocomposites for higher temperature application
  35. The influence of grain refinement on the corrosion mechanism of 7475 aluminium alloy
  36. Modelling the influence of the grain size distribution on the properties of nanometals
  37. Hybrid functional applied to the study of properties of narrow and wide band gap semiconductors
  38. Recrystallization and Grain Growth in Nano-structured Austenitic Stainless Steel under Electric Current Heating
  39. Effect of deformation and strain rate on diminishing of microstructure of aluminium alloys (AlCu4Zr0.5 and AlZn6Mg3CuZr)
  40. Grain refinement in CuCrZr by SPD processing
  41. Tailoring mechanical properties of nano-structured Eurofer 97 steel for fusion applications
  42. Microscopic and surface analytical characterization of TiO2 nanotubes produced by anodic oxidation and thermal treatment 
  43. Investigation of cells interactions with textile scaffolds for bone tissue enginnering
  44. Culture of osteoblasts on nanostructured titanium – preliminary observation
  45. Electrospun polymeric fibers for cartilage regeneration
  46. Modelling of plastic deformation of nano-polycrystalline materials
  47. Preliminary examinations of mechanical properties of DLC and novel DLC-polymer hybrid coatings for resurfacing hip prostheses
  48. Optimization of the polymeric scaffolds for bone tissue engineering fabricated by rapid prototyping method
  49. Bone tissue engineered product based on human bone derived cells and polyurethane scaffold
  50. Molecular statics simulation of nanoindentation on nanocrystalline copper
  51. Novel method for bone tissue scaffold fabrication. Influence of composition chitosan/beta-TCP matrixes on mechanical and biological properties.
  52. Microstructural and mechanical characterization of zirconia based composite
  53. Modeling of order-disorder phase transition in intermetallic compounds
  54. Optimization of polyurethane structure as the potential materials for bone tissue engineering applications
  55. Fabricationg polyurethane/calcium carbonate composite scaffold for bone tissue engineering
  56. Polyurethane nano-composites with luminescence properties for optics and optoelectronics applications.
  57. Polymer-TiO2 nanocomposites for soft tissue engineering
  58. Tailoring mechanical properties by grain refinement and particle redistribution
  59. Stochastic Approach To The Changes In The Mechanical Properties Of Nano-Crystalline Materials Induced By Grain Growth
  60. Surface effect on atomic ordering in nano-layered L10 AB binaries: multiscale Monte Carlo Simulation
  61. Characterization of nanopowders
  62. Microstructure and mechanical properties of HE-treated titanium depending on its initial state
  63. Influence of hydrostatic extrusion parameters on the microstructure and mechanical properties of 6082 aluminium alloy
  64. The effect of grain size distribution on mechanical properties of nanometals
  65. Morphological and surface analytical characterization of chemically pretreated Ti surfaces intended for biomedical applications
  66. Electron microscopy studies of magnesium hydride
  67. Microstructure and mechanical properties of 7475 aluminium alloy processed by SPD methods
  68. Investigation of aqueous surface processes and corrosion mechanisms of Al-(Cu)-Fe-Cr quasicrystaline approximant
  69. Characterization of the effects of hydrostatic extrusion on structure and surface properties of 303 austenitic stainless steel
  70. The Effect of Hydrostatic Extrusion on the Corrosion Stability of Austenitic Stainless Steels
  71. The Effect of Hydrostatic Extrusion on Resistance of 316 Austenitic Stainless Steel to Pit Nucleation
  72. Nanomaterials in dental applications
  73. Nanostructure formation in austenitic stainless steel
  74. Evaluation of crystal structure and polytypism of SiC in microwave sintered diamond-SiC composite by TEM and HR-TEM
  75. Hydrogen induced changes in 316L stainless steel microstructure
  76. Statistical model of grain growth in polycrystalline nanomaterials
  77. Repair and regeneration of osteochondral defects in the articular joints
  78. Corrosion resistance of nanostructured titanium
  79. Effect of surface treatment on the microstructure of TA6V
  80. Predicting site occupation of Fe in B2 NiAl from ab initio computations
  81. Structure and properties of polyurethane/YAG:Tb3+ nano-composites with luminescence properties
  82. Structure and thermal properties of epoxy resins nano-composites with flame retardants
  83. The influence of ZrO2 containing 10% Eu 3+ on the polyurethane hard domain structure of nano-composites with luminescence properties
  84. An influence of boehmite modification on the dispersion in the polyurethane matrix
  85. Materials hardness estimation by simulation of the indentation process
  86. Elastomeric nanocomposites with bioactive and nanocrystalline TiO2
  87. Stability of second phase particles during processing by hydrostatic extrusion
  88. The influence of nano - filler on microstructure homogeneity and selected properties of dental ceramic - polymer composites
  89. Grain Boundary Migration in Nanocrystalline Iron
  90. Thermal properties of L10-TiAl from first principle calculations
  91. Structural stability of zirconia ceramic in water and acid solutions
  92. The influence of the structure of metastable τ - phase on magnetic hysteretic properties of Мn55.5Аl44С0.5 alloy
  93. Morphology and chemical characterization of Ti surfaces modified for biomedical applications
  94. Evaluation of degradation degree of dental hybrid composite used as permanent fillings
  95. Optimization of particle reinforced lead-free solders
  96. Microstructural evaluation during particles addition to lead-free solders
  97. Thermal stability of hybrid polyurethane and modified boehmite
  98. Applications of quantitative image analysis to the description of the morphology of hybrid polyurea-nitryle-urethanes
  99. Improvement of wetting and bonding of SiO2 ceramics and urea-urethane elastomer
  100. A hybrid atomistic-continuum finite element modelling of locally disordered crystalline structure
  101. The role of the weak points in the corrosion resistance of hydrostatically extruded steel porducts
  102. The size effect in strength and fracture toughness of deformation origin submicro- and nanomaterials.
  103. The influence of hydrostatic extrusion on mechanical properties and tribological characteristics of an austenitic stainless steel
  104. Fabrication and micro-structure characterization of Al2O3/Ni-P composites with interpenetrating phases
  105. Hydrostatic extrusion of intermetallic Ti-Al layers
  108. Mechanical properties of aluminium processed by equal channel angular pressing
  109. Model for intermetallic phase and intermetallic compound solidification during diffusion soldering
  110. Texture Development in Model Al-Li Alloy Subjected to Severe Plastic Deformation
  111. The Influence of hydrostatic extrusion on microstructure of 6082 aluminum alloy
  112. Combination of ECAP and Hydrostatic Extrusion for ultra-fine grain (UFG) microstructure generation in 99.98% nickel.
  113. Microstructure refinement under high plastic strain rates in hydrostatic extrusion process
  114. Influence of severe plastic deformation on PLC effect in Al 5XXX alloy
  115. Mechanical properties and deformation behaviour of ultra-fine grained nickel.
  116. Formation of ultrafine gradient structure in hard magnetic alloy Fe-30%Cr-8%Co
  117. Sintering temperature effect on structure and properties of Al2O3/Ni-P composites with interpenetrating phases
  119. SEM investigations of tooth/ filling bonding
  120. Measuring the Grain Size Distribution of Pr-doped Zirconia Nanopowders obtained by Microwave Driven Hydrothermal Synthesis
  121. Nanometals for medical applications
  122. Effect of sever plastic deformation method on microstrucure and mechanical properties of Al and Cu
  123. The influence of twin bands density on microstructure of 316LVM austenitic stainless steel subjected to transverse rolling
  124. Microstructure evaluation in an Al-Li alloy processed by severe plastic deformation
  125. Polymer matrix composites with nanoparticles of TiC obtained by a sol-gel method
  126. Annealing temperature effect on residual stresses in 316L steel subjected to HPT process
  130. Modelling the interaction of crack tip with nanostructure, which creating by deformation.
  133. Atomic-scale Ab-initio computations of the B2-RuAl
  134. Ab-initio calculations of elastic properties Ni3Al and TiAl under pressure
  135. In-situ preparation and characterization of novel polyester/TiO2 nanostructured composites
  136. Evaluation of fatigue behaviour of elastomeric biomedical polymers
  137. Modelling of the Influence of the Grain Size Distribution on the Grain Growth in Nanocrystals
  138. Ductility of Nanocrystalline Materials Processed by Severe Plastic Deformation
  139. Structural-strength aspects of glass/metallic composite based on Co-Cr-Mo implantation alloy
  140. Microstructure and mechanical properties of binary Al-Li alloys processed by ECAP
  141. Microstructure of the ceramic - polymer composites for dental applications
  142. Effect of Non-conventional Large Deformations on Microstructure and Properties of Metals
  143. Excellent Mechanical Properties of Nickel Processed by High Pressure Techniques
  144. Morphology and properties of oxide films formed on the nanocrystalline 316L austenite steel
  145. Al2O3-Fe functionally graded materials fabricated under magnetic field
  146. Professor CZOCHRALSKI - Distinguished Scientist and Inventor, Founder of the Modern Materials Science
  147. The influence of temperature and pressure on possibility of obtaining Al2O3/Ni-P nanocomposite through hot pressing process.
  148. Mechanical properties nanostructured iron obtained by different methods of Severe Plastic Deformation
  149. Strain localization in nanocrystalline iron after Severe Plastic Deformation
  150. Non-elastic behaviours of high-porosity ceramics and ceramic-polymer composites
  151. The Superplasticity of Hard Magnetic Alloy Fe-23wt.%Co-30%Cr with Submicrocrystalline Structure
  152. Microstructure of Ni-P thin layers obtained by a chemical method
  153. Hydrostatic extrusion and nanostructure formation in an aluminium alloy
  154. Quantitative Description of Microstructure of Nano-materials
  155. The Structure and Mechanical Properties of Low Carbon Low Alloy Steel Subjected to Severe Plastic Deformation
  156. Studies of Ni-P Thin Films by Electroles Deposition Method
  157. Stereology of Nanomaterials
  158. Targeted Research Project: Metallic, Ceramic and Organic Nanomaterials: Processing - Structure - Properties - Applications
  159. Materials Research in Poland

Presentation: Poster at E-MRS Fall Meeting 2008, Symposium L, by Tomasz Jaroszewicz
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-07-08 10:49
Revised:   2009-06-07 00:48
© 1998-2021 pielaszek research, all rights reserved Powered by the Conference Engine