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A combination of microCT and FEM methods for development of a new scaffold for bone regeneration

Marcin K. Heljak ,  Jakub Jaroszewicz ,  Wojciech Swieszkowski ,  Krzysztof J. Kurzydlowski 

Warsaw University of Technology, Faculty of Materials Science and Engineering (InMat), Wołoska 141, Warszawa 02-507, Poland


The main aim of the work was to develop a new method for generation and validation of numerical models of 3D porous scaffolds based on in situ micro- CT examination.  The validated numerical models of the scaffold could be used in preclinical evaluation how the scaffold fulfill its role in the process of bone tissue regeneration.
The main problem with structural modeling of the scaffolds and the other porous structures is creating of reliable geometrical models, which reflect the details of such complicated structures. In the study, a finite element model of the highly porous polymeric scaffolds fabricated via  Solid Free Form Fabrication Method (SFFM) was prepared based on in situ X-ray micro-CT examination. A novelty of the method is that during the micro-CT examination the sample is compressed and at each load step geometry of the scaffold was scannedand the force-displacement characteristic is recorded. Based on the CT dataset of the unloaded sample the 3D the finite element model (FEM) of the scaffold was created. To validate the numerical model  FE analysis simulating the compression test in the micro-CT scanner was performed. At each load step the computed displacements of selected points of scaffold domain were compared with the displacements of the corresponding points belong to the experimental data. The created numerical model shows the satisfactory consistence with experiment in linear range of carried out compression test. The next step is to use the created numerical model in inverse analysis for finding nonlinear material properties of the scaffold.    


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Presentation: Oral at E-MRS Fall Meeting 2009, Symposium F, by Marcin K. Heljak
See On-line Journal of E-MRS Fall Meeting 2009

Submitted: 2009-05-24 22:49
Revised:   2009-06-07 00:48