We synthesized potential biosensors, based on Er, Yb doped NaYF₄ nanoparticles, with up-conversion of infrared light capable to emit in the visible and ultraviolet range. They could be potentially applied for targeted therapy in cancer, through up-conversion to the ultraviolet radiation. Biological systems excited by the near infrared energy exhibit less autofluorescence than if excited by the visible or the ultraviolet light. Visible emission permits to observe physiologically relevant processes within cells, and the emission of the ultraviolet light allows for the selective elimination of cancer cells by generating free radicals.
   We were able to synthesize NaYF₄ nanoparticles doped with different amounts of rare earth ions, providing an efficient energy up-conversion. After functionalization by PVP or oleic acid, we were able to introduce these particles into HeLa cancer cells, where we examined their localization in the function of both, incubation time and particles concentration. We performed preliminary attempts to bio-functionalize nanoparticles for specific locations in the cancer cells.

Acknowledgements: The research was partially supported by the European Union within European Regional Development Fund, through grant Innovative Economy (POIG.01.01.02-00-008/08) and was partially supported by the grant from the Polish National Centre for Research and Development NR13004704 and Center of Excellence. This work has been done in the NanoFun laboratories co-financed by the European Regional Development Fund within the Innovation Economy Operational Programme, the Project No. POIG.02.02.00-00-025/09/.

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