The cytotoxic activity in vitro of glycosides of indolo[2,3-b]guinoline having daunosamine or acosamine moiety was evaluated. In our research we used human colon cancer (LoVo), uterine sarcoma (MES-SA), promyelocytic leukemia (HL-60), lung cancer (A-549) and melanoma (Hs294T) cell lines. We found that all the indoloquinolines studied were cytotoxic against the cells of all cancer lines used. They showed the highest cytotoxic activity against human leukemia cell line (HL-60) and the lowest against the human melanoma cell line (Hs294T) as well as against the human colon cell line (LoVo) (Table1.)

To define antitumor activity the compound IBR-5 in vivo we applied mouse leukemia cell line (P-388). The results of our research show toxicity of studied compound in higher range of doses (30, 50 and 100 mg/kg). The average survival time (AST) of mice, which was administered with the compound IBR-5 in higher doses was 7 days and for control mice 12 days. Additionally in lower range of doses (10, 5, 1 mg/kg) the compound did not show antitumor effect. The average survival time of mice which were administered with the compound in lower doses was comparable to AST of control mice.

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1. Synthesis of new 5H-indolo[2,3-b]quinoline derivatives with a high selective cytotoxic activity
2. Hplc study of Cilostazol tablets: assay and release profile determination
3. Administration of isothiocyanate-derived mercapturic acids inhibits solid tumor growth of 4T1 murine mammary carcinoma cells in BALB/c mice
4. Preliminary studies on application of library of artificial receptors for differentiation of metabolites in urine of healthy and cancer mice
5. Application of the new data processing method for photodiode array detector in the analysis of drug substances
6. Starch derivatives as vehicles for drug delivery in anticancer therapy
7. Mercapturic acids as a naturally occurring isothiocyanates prodrug form with site-directed delivery system built-in based on an oxidative environment of the tumor
8. Synthesis and biological activity of novel N,N-cyclic-2,4-dihydroxythiobenzamide derivatives
9. Anticancer activity of vitamin D, genistein and indoloquinoline analogs
10. Validation of HPLC methods for analyzing the chemical purity of cilostazol
11. Identification of degradation products of cilostazol drug substance
12. Synthesis and anticancer activity of acetylenic derivatives of betulin
13. An application of accelerator mass spectrometry (AMS) in pediatric clinical studies. Paracetamol, midazolam and spironolactone radiosynthesis and certification.
14. 5H-indolo-[2,3-b]quinolines loaded polymeric micelles
15. HPLC methods for in–process control and chemical purity determination of olopatadine
16. An improved process for the preparation of 2-amino-N-tert-butyl-2-cyanoamide hydrochlorie.
17. Interaction of endotoxin and polymyxin B in B16 mouse melanoma model of metatstasis
18. Anticancer activity of the conjugates:  modified fibrinogen – methotrexate.
19. Synthesis and cytotoxic activity of new Pt (II) complexes with nitropyrazoles in aerobic and hypoxic conditions
20. Vitamin D analogs enhance the activity of imatinib mesylate in human non-small cell lung cancer model
21. Colon cancer treatment with the use of vitamin D analogs and irinotecan 
22. Novel bifunctional synthetic isothiocyanates with high antiproliferative activity
23. Naturally occurring hydroxyalkyl isothiocyanates and isothiocyanatoalkyl benzoates - structure-activity and structure-mechanism of action relationship studies.
24. Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. 
25. Antitumor activity of carrier-methotrexate conjugates.
26. CLA derivatives as functional food compounds
27. New acetylenic derivatives of betulin with anticancer activity
28. Analytical control of synthesis and determination of BR-S by HPLC
29. Optimization of BR-8 synthesis
30. Catalytic synthesis and antiproliferative activity in vitro of polisubstituted isoxazolopyridine derivatives.
31. HPLC Methods for Stress Testing of ZL-S Drug Substances
32. Steroid profile of Asplenium cuneifolium
33. The influence of (24R)-1,24- dihydroxyvitamin D₃ on the anticancer activity of 5-fluorouracil in human colon cancer model
34. Comparison of antiproliferative activity of the natural isothiocyanates and their mercapturic derivatives.
35. Could the calorically restricted ketogenic diet be an     effective alternative or supportive therapy for breast cancer?
36. Analogs of genistein and its possible anti-metastatic properties
37. The influence of novel analogs of vitamin D₃ on the antiproliferative activity of cisplatin or doxorubicin on human promyelocytic leukaemia cell line HL-60 
38. New amino acid and peptide derivatives of 5H-indolo[2,3-b]quinoline and their biological activity.
39. Zolmitriptan synthesis and in-process control by HPLC methods
40. The cytotoxic activity of glycosides of indolo[2,3-b]quinoline derivatives.
41. Disubstituted indolo[2,3-b]quinoline derivatives - the cytotoxic activity in vitro against various human tumor cell lines.
42. Mono substituted 5H- and 6H-indolo[2,3-b]quinoline derivatives and their ability to overcome the barrier of drug resistance.
43. Synthesis and antiproliferative activity in vitro of (4-substituted-2-butynylthio)quinolines
44. New calcipotriol analogs, their toxicity and antitumor activity in vivo in comparison to the affinity with VDR and DBP
45. Synthesis and cytostatic activity of new 1-substituted 6H-pyrido[4,3-b]carbazole derivatives
46. The new analogs of genistein decrease mitochondrial membrane potential and activate caspase-3
47. Development of HPLC and GC methods for analysis of Zolmitriptan of pharmaceutical purity
48. Optimization of AR-3 synthesis
49. New amino acid derivatives of 6H-indolo[2,3-b]quinolines
50. Influence of Transformation of the Amino Group in Anthracyclines into -N=CH-N< or -N=CH-O- Group on Their Biological Properties
51. PRIMARY CYTOTOXICITY EVALUATION OF NEW HETEROCYCLIC SYSTEMS WITH PYRIDODIAZEPINE.
52. SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY IN VITRO OF NEW 2-AMINOBENZIMIDAZOLE DERIVATIVES. PART 3. REACTIONS OF 2-ARYLIDENE- AMINOBENZIMIDAZOLE WITH SELECTED 1,3-DIKETONES.
53. CHARACTERIZATION OF ARIPIPRAZOLE SOLVATE WITH ETHANOL AND POLYMORPHIC FORMS PRODUCED DURING ITS HEATING
54. HPLC SEPARATION AND DETERMINATION OF ZIPRASIDONE
55. OPTIMIZATION OF THE CHROMATOGRAPHIC SEPARATION BY HPLC METHOD AND CONFIRMATION OF THE IDENTITY OF CHOSEN ESCITALOPRAM OXALATE INTERMEDIATE PRODUCTS
56. CONJUGATED LINOLEIC ACIDS PREPARATIONS AS EFFECTIVE NUTRACEUTICS
57. SYNTHESIS OF GLIMEPIRIDE - CRYSTAL STRUCTURE ANALYSIS STEP BY STEP
58. THE ANTIMETASTATIC EFFECT OF BACTERIOPHAGE T4* ADMINISTRATED IN COMBINED TREATMENT WITH SELECTED CYTOSTATICS IN MICE WITH B16 MELANOMA
59. GC METHOD FOR QUANTITATIVE DETER- MINATION OF RESIDUAL 2-(2-CHLORO- ETOXY)ETHANOL (CEE) AND N-METHYL- 2-PYRROLIDINONE (NMP) IN PHARMACEU- TICAL ACTIVE SUBSTANCE
60. SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF DIACETYLENIC THIOQUINOLINES
61. SYNTHESIS AND CYTOTOXIC ACTIVITY OF 10-DEACETYL-10-PROPARGILPACLITAXEL
62. MONO SUBSTITUTED 5H-INDOLO[2,3-B]- QUINOLINE DERIVATIVES AND THEIR ABILITY TO OVERCOME THE BARRIER OF DRUG RESISTANCE.
63. DISUBSTITUTED INDOLO[2,3-b]QUINOLINE DERIVATIVES. THE CYTOTOXIC ACTIVITY IN VITRO AGAINST VARIOUS HUMAN TUMOR CELL LINE.
64. ANTITUMOR EFFECT OF CISPLATIN OR FLUOROURACIL IN COMBINED TREATMENT WITH (24R)-1,24-DIHYDROXYVITA- MIN D₃
65. FIRST ROUND STUDIES ON LEWIS LUNG CARCINOMA ACTIVITY OF THE NEW LEAD STRUCTURES IN THE ISOXAZOLE HETEROCYCLIC SYSTEM
66. GENISTEIN, ITS NEW ANALOGS AND COMPLEXES - THE ANTIPROLIFERATIVE EFFECTS ON HL-60 LEUKEMIA CELL LINE
67. COMBINATION OF: IMATINIB, PRI-2191 AND CYTOSTATICS - THE ANTIPROLIFERATIVE EFFECTS ON HL-60 LEUKEMIA CELL LINE
68. ANTIPROLIFERATIVE ACTIVITY IN VITRO OF DIASTEREOMERIC ANALOGUES OF VITAMIN D3 AGAINST NORMAL AND CANCER CELL LINES
69. NEW IMPROVED METHOD OF POLYMORPHIC α FORM OF IMATINIB MESYLATE (GLEEVEC^®) SYNTHESIS.
70. ¹H AND ¹³C NMR DATA FOR INDOLO[2,3-b]QUINOLINES - AMINOGLYCOSIDE HYBRIDS, A NOVEL POTENT ANTICANCER DRUG FAMILY .
71. NEW SYNTHESIS OF 11-(1-PIPERAZINYL)- DIBENZO[b,f][1,4]THIAZEPINE, A CRUCIAL INTERMEDIATE IN QUETIAPINE PRODUCTION.