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OPTIMIZATION OF THE CHROMATOGRAPHIC SEPARATION BY HPLC METHOD AND CONFIRMATION OF THE IDENTITY OF CHOSEN ESCITALOPRAM OXALATE INTERMEDIATE PRODUCTS
|Agata E. Kamieńska-Duda , Beata Śmigielska , Piotr A. Baran , Łukasz S. Kaczmarek
Pharmaceutical Research Institute (IF), Rydygiera 8, Warszawa 01-793, Poland
Escitalopram (fig. 1) is an oral drug that is used for treating depression and generalized anxiety disorder. It works by affecting neurotransmitters in the brain, the chemical messengers that nerves use to communicate with one another. Neurotransmitters are made and released by nerves and then travel to other nearby nerves where they attach to receptors on the nerves. Some neurotransmitters that are released do not bind to receptors and are taken up by the nerves that produced them .
An optimization of the method for the separation of the previously selected intermediate products by High Performance Liquid Chromatography (HPLC) is described. The determination of the chemical identity of the isolated compounds was performed. Different spectroscopy methods were used for this propose: Infrared Spectroscopy (FT-IR) and Nuclear Magnetic Resonance (NMR).
 E. Saltiel, Pharm D. MedicineNet.Com
Presentation: Poster at V Multidyscyplinarna Konferencja Nauki o Leku, by Agata E. Kamieńska-Duda
See On-line Journal of V Multidyscyplinarna Konferencja Nauki o Leku
Submitted: 2006-03-03 11:07 Revised: 2009-06-07 00:44