Aripiprazole (7-[4-[4- (2,3-dichlorophenyl) piperazin-1-yl] butoxy]-3,4- dihydro- 1H quinolin-2-one) is an anti - psychotic drug.

In this work a solvate with ethanol of Aripiprazole (2(C₂₃H₂₇Cl₂N₃O₂)·C₂H₅OH) was fully characterized by means of the single crystal and the powder X-ray diffraction [1]. The studies revealed that the solvate crystallizes in space group P-1, Z=2 with unit cell parameters: a=7.796(2), b=10.694(4), c=15.608(7) Å and a=84.61(3), b=80.35(3), g=73.43(3)^o. The ethanol molecule is incorporated in dimmers of Aripiprazole between chloro-derivative aromatic rings.

Thermal analysis and IR techniques additionally confirmed a presence of the ethanol molecule in Aripiprazole. XRPD, IR techniques revealed that the polymorph I can be obtained by a heating the solvate at the temperature of 100 ^oC but DSC analysis showed a presence of another form dash - the polymorph II [2]. Probably a quantity of polymorph II was too small for XRPD and IR detection. Further heating, up to 145 ^oC (temperature between two endo- peaks on a DSC curve), brought about a growth of polymorph II seeds what was observed by XRPD, IR and DSC techniques.

[1] "Sposób wytwarzania aripiprazolu w farmaceutycznie użytecznych formach polimorficznych", Ł.Kaczmarek, M.Łaszcz, A.Pietraszko, W.Szelejewski (na rzecz Polpharma SA) Data zgłoszenia 16.12.2005, Nr zgłoszenia P-378363.

[2] "Study on Crystal Transformation of Aripiprazol", Satoshi Aoki, Takuji Bando, Noriyuki Kobayshi, The fourth Japan-Korea symposium on separation Technology.

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