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Ewa Chojecka-Koryn ,  Hanna M. Beczkowicz ,  Wojciech J. Szczepek ,  Wojciech Łuniewski 

Pharmaceutical Research Institute (IF), Rydygiera 8, Warszawa 01-793, Poland

Quinones and hydroquinones are widely used in the syntheses of organic compounds including pharmaceutical substances preparations. There is currently considerable interest in the role of this group of substances as antioxidants and biologically active components.

For detection of their presence in the reaction products and to evaluate the purity of the prepared samples, a simple analytical method was developed.

High-Performance Liquid Chromatography (HPLC) is an analytical technique appropriate for the separation and determination of organic analytes in various samples, especially biological, pharmaceutical, environmental, and industrial.

Figure 1 q10_1.gif

Synthesized compounds representing structures I and II (Figure 1) were well determined and separated by reversed phase high-performance liquid chromatography in isocratic and gradient conditions. The optimization of the simultaneous determination of six compounds, shown on the Figure 1, was performed. The peaks in the chromatograms of a mixture were identified based on the retention times of isolated components injected separately. Additionally chemical structure of examined compounds was established using spectrometric methods.


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Related papers

Presentation: Poster at V Multidyscyplinarna Konferencja Nauki o Leku, by Ewa Chojecka-Koryn
See On-line Journal of V Multidyscyplinarna Konferencja Nauki o Leku

Submitted: 2006-03-15 10:53
Revised:   2009-06-07 00:44