For the first time two crystalline forms of the same compound (linezolid polymorphs) were investigated by means of the solid-phase ECD and VCD spectra [1]. The ECD spectra show distinct differences and the band at 221 nm serves as a diagnostic one because it is present in form II but absent in form III. The VCD spectra strongly differ in the diagnostic carbonyl absorption range exhibiting two relatively strong bands of opposite signs. The results obtained for linezolid clearly demonstrate the usefulness of solid-phase circular dichroism spectroscopy as a new and valuable tool for distinguishing polymorphic forms of chiral compounds.

[1] J. Frelek, M. Górecki, M. Łaszcz, A. Suszczyńska, E. Vass, W.J. Szczepek, Chem. Commun., DOI: 10.1039/C2CC31207G 

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