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High-yielded method of synthesis of voriconazole.

Kinga Burakowska ,  Michał Chodyński ,  Hanna Fitak ,  Małgorzata Krupa ,  Andrzej Kutner ,  Marta Łaszcz 

Instytut Farmaceutyczny (PRI), Rydygiera 8, Warszawa 01-793, Poland

The description of the efficient synthesis of voriconazole - active substance of antifungal medicine from triazol group with wide-spectrum of activity was presented. High efficiency and the chemical and enantiomeric purity of the product were reached by the modification of the critical steps of the synthesis described by Pfizer company in the basic patent. It was possible due to the use of a structurally advanced intermediate and using Metz Syn10

apparatus Radleys company for chemical reaction condition control.


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Related papers

Presentation: Poster at VI Multidyscyplinarna Konferencja Nauki o Leku, by Kinga Burakowska
See On-line Journal of VI Multidyscyplinarna Konferencja Nauki o Leku

Submitted: 2008-03-12 13:44
Revised:   2009-06-07 00:48