Apart from polymorphs, hydrates of active pharmaceutical ingredient are highly desirable in the pharmaceutical industry. In hydrates the small water molecule can fill structural voids, as well as by acting as a hydrogen donor and/or acceptor it may structuralize a crystal majority into stable crystal structures [1]. Due to high solubility and biocompatibility, amine hydrochlorides are often chosen as drug products. They can easily form hydrates because charged ammonium and chloride ions are in proximity to water molecules through the hydrogen bonds [1, 2].

[1] S.R. Byrn, R.R. Pfeiffer and J.G. Stowell, Solid-State Chemistry of Drugs, second ed., SSCI, Inc., West Lafayette, Indiana, 1999.
[2] A. Obata, M. Yoshimori, K. Yamada and H. Kawazura, Bull. Chem. Soc. Jap., 58 (1985).
[3] E. Lorenc-Koci, S. Wolfarth, Eur. J. Pharmacol., 385 (1999) 39-46.

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