ROPINIROL - GENERIC DRUG FOR PARKINSON'S DISEASE
|Urszula Chmielowiec , Jerzy Winiarski , Teresa Paszkowska-Reymer , Wioleta Maruszak|
Pharmaceutical Research Institute (IF), Rydygiera 8, Warszawa 01-793, Poland
Multistep synthesis of 4-[2-(dipropylamino)-etyhl]-1,3-dihydro-2H-indol-2-one hydrochloride (ropinirole hydrochloride) was elaborated in Pharmaceutical Research Institute. From ten steps of synthesis - reduction of starting 2-methyl-3-nitrobenzoic acid to the corresponding alcohol, reaction of chain extension and reductive cyclization to indolone ring play significant role in the process of the formation find product.
Development of synthetic steps one to four was based on the literature data  and steps five to ten were carried out according to the patent procedure .
1. Bhaskar Kanth J.V., Periasamy M., J. Org. Chem. 1991, 56, 5964-5965.
2. Patent EP 113964 (1982).
Presentation: Poster at V Multidyscyplinarna Konferencja Nauki o Leku, by Urszula Chmielowiec
See On-line Journal of V Multidyscyplinarna Konferencja Nauki o Leku
Submitted: 2006-04-07 10:34 Revised: 2009-06-07 00:44
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