Search for content and authors


Wiesława Walisiewicz-Niedbalska 1Andrzej W. Lipkowski 1,2Bożena Patkowska-Sokoła 3Robert Bodkowski 3Adam Opolski Joanna Wietrzyk 

1. Industrial Chemistry Research Institute (ICRI), Rydygiera 8, Warszawa 01-793, Poland
2. Polish Academy of Sciences, GBAF, Medical Research Center (CMDiK PAN), Pawinskiego 5, Warszawa 02-106, Poland
3. Agricultural University of Wrocław, Chełmońskiego 38d, Wrocław 51-630, Poland


Nutraceutics became important components of successful therapies. Recently particular attention has been focused on linoleic acid isomers (CLA) containing conjugated double bonds.

Conjugated linoleic acids (CLA) represent a family of octadecadienoic acids which constitute a mixture of geometric and position isomers of linoleic acid in which the double bond occurs in the positions ranging from 6,8 to 9,11 and to 10,12. The 9c,11t C18:2 acid is the predominant isomer.

The content of the 9c,11t C18:2 isomer in the cow milk fat, goat milk fat and sheep milk fat were found to oscillate within the ranges 0.65-1.8%, 0.3-1.2% and 1.2-2.3%, respectively. The sheep milk fat shows the highest content of the isomer.

Sheep milk fat containing 2% of the 9c,11t C18:2 conjugated linoleic acid (CLA) isomer was selected to study the antiproliferative activity of this isomer. Sheep milk fatty acids containing 2.0% of the 9c,11t C18:2 isomer, and the acids enriched in this isomer up to 12.1%, (N-CLA), were used in the studies.

The product (N-CLA) contained 15.0% of the 9c,11t C18:2 isomer and about 8.0% of the 11t C18:1. The sheep milk fatty acids composition and the product enriched in CLA (N-CLA), and also a commercial CLA preparation, were studied in antiproliferative activity against few lines of human cancer.

The effect of CLA-enriched preparation of sheep milk fatty acids, N-CLA, revealed higher antiproliferative activity than standard pure CLA and sheep milk fatty acids.

The present study was carried out in the framework of the Research Projects 3 T09 B 059 26 financed by the Ministry of Education and Science.


Legal notice
  • Legal notice:

Related papers

Presentation: Poster at V Multidyscyplinarna Konferencja Nauki o Leku, by Wiesława Walisiewicz-Niedbalska
See On-line Journal of V Multidyscyplinarna Konferencja Nauki o Leku

Submitted: 2006-03-02 12:13
Revised:   2009-06-07 00:44