In our previous studies, two types of isoxazole derivatives weres tested on anticancer activities [1, 2, 3]. In this communication the effect in vivo of the new lead structures applied intraperitoneally on the growth of experimental Lewis lung carcinoma (LLC), transplanted subcutaneously, is presented. We observed the tendency of growth inhibition of LLC cancer by compound R13 with the tumor growth inhibition (TGI) achieving 30%. In the case of other compounds tested (R11, R12, R14 and R15) we observed no effect or stimulation of LLC tumor growth. The increase in life span (ILS%) of mice, which was administered with the compounds was 7-17% and was not statistically significant. Observation of body weight shows no toxicity of compounds tested. In conclusion, we show that compound R13, may inhibit tumor growth. Other compounds in these conditions, may stimulate Lewis lung cancer growth. Our studies on these activities and their potential application are discussed.

This work was supported by the State Committee for Scientific Research (KBN) Grant No. 3 P05F 012 24

References

[1] St. Ryng and D. Duś : "The 5-amino-3-methyl-4-ureidoisoxazoles, synthesis and antileucemic activity", Pharmazie, 1994, 49, H. 10.

[2] St. Ryng; W. Malinka and D. Duś: " Synthesis and anticancer properties of 5-substituted derivatives of 3-methylisoxazolo-[5,4-d]-1,2,3-triazine-4-ones and 3-methyl-5-triazene --4-isoxazolecarboxylic acid ethyl ester" Il Farmaco 1997, 52(2), 105.

[3] S. Ryng, M. Zimecki, C. Radzikowski, A. Opolski, J. Wietrzyk: " Correlations between the immunological and anticancer properties in the isoxazole derivatives" The First Multidisciplinary Conference on Drug Research, Muszyna 3-5. 03. 1999.

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