Title compounds were preliminary tested for their immunotropic activities in several experimental models such as: the secondary humoral immune response of mouse splenocytes to sheep red blood cells (SRBC), the proliferative response of splenocytes to concanavalin A and lipopolysaccharide (LPS)-induced production of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) in cultures of human peripheral blood mononuclear cells (PBMC). Each of the four studied compounds showed different characteristics in affecting the tested immune parameters. Our studies on these activities and their potential application are discussed.

This work was supported by the State Committee for Scientific Research (KBN) Grant No. 3 P05F 012 24

Reference

Ryng S, Zimecki M, Maczynski M, Chodaczek G, Kocieba M.: Immunosuppressive activity of an isoxazolo[5,4-e] triazepine - compound RM33. I. Effects on the humoral and cellular immune response in mice. Pharm Rep, 2005, 57, 195-202

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