Intensive studies on new, biologically active isoxazole derivatives, have been conducted for the last few decades. We synthesized a group of monocyclic and bicyclic isoxazole derivatives. In the group of monocyclic compounds, the pharmacophore structure was a fragment of 5-amino-3-methyl-4-isoxazolecarboxylic acid. The importance of the pharmacophore structure of 5-amino-3-methylo-4-isoxazolecarboxylic acid, contained in N'-substituted hydrazides, semicarbazides, semithiocarbazides of that acid with immunosupressory activities and isoxazoleoxadiazol, isoxazolopirazol and isoxazolopirol, with high immunomodulatory activities, was confirmed in several patents.

Looking for active immunomodulators we synthesized new 4-substituted 3-(5-amino-3-methyl-4-isoxazole)-1,2,4,-triazoline-5-tione and 5-substituted 2-(5-amino-3-methyl-4-isoxazole)-1,3,4-tiadiazole derivatives. We obtained the compounds in reaction of 5-amino-3-methyl-4-isoxazolecarboxylic acid thiosemicarbazides with conc. sulphuric acid or sodium hydroxide.

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1. Immunomodulatory activity of new isoxazole derivatives
2. Effect  of  5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on primary humoral immune response in mice
3. Immunorestoring activity of isoxazole derivative R-13
4. Biological activities of new amidrazone derivative and its copper (II) complex
5. Synthesis and cytotoxic activity of new Pt (II) complexes with nitropyrazoles in aerobic and hypoxic conditions
6. Searchıng for new ısoxazole derıvatıves wıth potentıal ımmunorestorıng actıvıty
7. Research into transformations of 5-amino-3-methyl- 4-isoxazolecarboxylic acid hydrazide under orthoesters influence
8. Electrochemical studies of Pt (II) complexes with potential bioreductive properties
9. Two examples of very closely related isoxazoles exhibiting opposite immunological activities
10. IMMUNOLOGICAL ACTIVITY OF DISUBSTITUTED SEMICARBAZIDE AND THIOSEMICARBAZIDE ISOXAZOLE DERIVATIVES
11. PRELIMINARY STUDIES ON IMMUNOTROPIC ACTIVITY OF THE NEW LEAD STRUCTURES IN THE ISOXAZOLE HETEROCYCLIC SYSTEM
12. FIRST ROUND STUDIES ON LEWIS LUNG CARCINOMA ACTIVITY OF THE NEW LEAD STRUCTURES IN THE ISOXAZOLE HETEROCYCLIC SYSTEM