Hypoxic conditions are usually the common feature of solid tumors resulting from their inefficient microvascular systems due to the rapid tumor growth¹. This behavior distinguished solid tumor cells from normal cells causing their resistance to the chemo- and radiotherapy but, on the other hand, also giving new opportunities for selective cancer treatment. In our approaches to the design and synthesis of targeted anticancer prodrugs for tumor site-specific activation we paid our attention to Pt(II) complexes with nitrodiazoles. This class of compounds potentially should exhibit dual mode of action, binding to DNA and undergo the bioreductive activation process. Presented poster summarizes electrochemical reduction potentials of the synthesized Pt(II) complexes in comparison with starting nitrodiazole ligands which will be a reasonable indicator of their bioreductive ability². Electrochemical data in connection with cytostatic activities and distribution coefficients (logP) of the compounds tested will be used in further design and synthesis of the new potentially bioreductive Cisplatin analogs.

References:

¹Chen Y., Hu L., Design of anticancer prodrugs for reductive activation, Med Res Rev., 2009, Jan, 29(1), 29-64.

²A. Zięba-Mizgała, A. Puszko, A. Regiec, J. Kuduk-Jaworska, Electrophilic properties of nitroheterocyclic compounds. Potential hypoxic cells radiosensitizers, Bioelectrochemistry, 2005, 65, 113-119.

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