A number of natural compounds with the antitumor activity have been found in our diet. Among them there is a large group of compounds known as isothiocyanates (ITC), the majority of which occur in plants, especially in Cruciferous vegetables like broccoli, cauliflower, cabbage and others. Highly reactive isothiocyanate (-NCS) group have an ability to simultaneously modulate multiple cellular targets involved in cancer development and its main targets are cysteine residues. The main metabolic pathway involved in isothiocyanates elimination from cells is the mercapturic acids pathway. The process starts from glutathione, an important redox state guardian, and leads to cysteine and N-acetylocysteine (NAC) conjugates. Interestingly, this metabolic products also exhibits antitumor activity.
We compared the antiproliferative activity of a group of natural isothiocyanates and their metabolites. In vitro studies on several lung and breast cancer cells lines were performed. We have showed that isothiocyanates can be strong antiproliferative agents with relatively low cytotoxicity towards normal cells. Moreover, our studies showed that the isothiocyanates metabolites not only posses the antiproliferative activity, but in many cases this activity is greater than activity of ITCs.  Because of that, and because of some other reasons (discussed in the paper), we believe that isothiocyanates metabolites could by both anticancer drugs and element of chemopreventive diet.

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1. Synthesis of new 5H-indolo[2,3-b]quinoline derivatives with a high selective cytotoxic activity
2. Administration of isothiocyanate-derived mercapturic acids inhibits solid tumor growth of 4T1 murine mammary carcinoma cells in BALB/c mice
3. Preliminary studies on application of library of artificial receptors for differentiation of metabolites in urine of healthy and cancer mice
4. Starch derivatives as vehicles for drug delivery in anticancer therapy
5. Mercapturic acids as a naturally occurring isothiocyanates prodrug form with site-directed delivery system built-in based on an oxidative environment of the tumor
6. Synthesis and biological activity of novel N,N-cyclic-2,4-dihydroxythiobenzamide derivatives
7. Anticancer activity of vitamin D, genistein and indoloquinoline analogs
8. Synthesis and anticancer activity of acetylenic derivatives of betulin
9. Interaction of endotoxin and polymyxin B in B16 mouse melanoma model of metatstasis
10. Anticancer activity of the conjugates:  modified fibrinogen – methotrexate.
11. Synthesis and cytotoxic activity of new Pt (II) complexes with nitropyrazoles in aerobic and hypoxic conditions
12. Vitamin D analogs enhance the activity of imatinib mesylate in human non-small cell lung cancer model
13. Colon cancer treatment with the use of vitamin D analogs and irinotecan 
14. Novel bifunctional synthetic isothiocyanates with high antiproliferative activity
15. Naturally occurring hydroxyalkyl isothiocyanates and isothiocyanatoalkyl benzoates - structure-activity and structure-mechanism of action relationship studies.
16. Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. 
17. Antitumor activity of carrier-methotrexate conjugates.
18. CLA derivatives as functional food compounds
19. New acetylenic derivatives of betulin with anticancer activity
20. Catalytic synthesis and antiproliferative activity in vitro of polisubstituted isoxazolopyridine derivatives.
21. Steroid profile of Asplenium cuneifolium
22. The influence of (24R)-1,24- dihydroxyvitamin D₃ on the anticancer activity of 5-fluorouracil in human colon cancer model
23. Could the calorically restricted ketogenic diet be an     effective alternative or supportive therapy for breast cancer?
24. Analogs of genistein and its possible anti-metastatic properties
25. The influence of novel analogs of vitamin D₃ on the antiproliferative activity of cisplatin or doxorubicin on human promyelocytic leukaemia cell line HL-60 
26. New amino acid and peptide derivatives of 5H-indolo[2,3-b]quinoline and their biological activity.
27. The cytotoxic activity of glycosides of indolo[2,3-b]quinoline derivatives.
28. Disubstituted indolo[2,3-b]quinoline derivatives - the cytotoxic activity in vitro against various human tumor cell lines.
29. Mono substituted 5H- and 6H-indolo[2,3-b]quinoline derivatives and their ability to overcome the barrier of drug resistance.
30. Synthesis and antiproliferative activity in vitro of (4-substituted-2-butynylthio)quinolines
31. New calcipotriol analogs, their toxicity and antitumor activity in vivo in comparison to the affinity with VDR and DBP
32. Synthesis and cytostatic activity of new 1-substituted 6H-pyrido[4,3-b]carbazole derivatives
33. The new analogs of genistein decrease mitochondrial membrane potential and activate caspase-3
34. New amino acid derivatives of 6H-indolo[2,3-b]quinolines
35. Influence of Transformation of the Amino Group in Anthracyclines into -N=CH-N< or -N=CH-O- Group on Their Biological Properties
36. PRIMARY CYTOTOXICITY EVALUATION OF NEW HETEROCYCLIC SYSTEMS WITH PYRIDODIAZEPINE.
37. SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY IN VITRO OF NEW 2-AMINOBENZIMIDAZOLE DERIVATIVES. PART 3. REACTIONS OF 2-ARYLIDENE- AMINOBENZIMIDAZOLE WITH SELECTED 1,3-DIKETONES.
38. CONJUGATED LINOLEIC ACIDS PREPARATIONS AS EFFECTIVE NUTRACEUTICS
39. THE ANTIMETASTATIC EFFECT OF BACTERIOPHAGE T4* ADMINISTRATED IN COMBINED TREATMENT WITH SELECTED CYTOSTATICS IN MICE WITH B16 MELANOMA
40. SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF DIACETYLENIC THIOQUINOLINES
41. SYNTHESIS AND CYTOTOXIC ACTIVITY OF 10-DEACETYL-10-PROPARGILPACLITAXEL
42. THE CYTOTOXIC GLYCOSIDES OF INDOLO[2,3-B]QUINOLINE DERIVATIVES. IN VITRO AND IN VIVO STUDIES
43. MONO SUBSTITUTED 5H-INDOLO[2,3-B]- QUINOLINE DERIVATIVES AND THEIR ABILITY TO OVERCOME THE BARRIER OF DRUG RESISTANCE.
44. DISUBSTITUTED INDOLO[2,3-b]QUINOLINE DERIVATIVES. THE CYTOTOXIC ACTIVITY IN VITRO AGAINST VARIOUS HUMAN TUMOR CELL LINE.
45. ANTITUMOR EFFECT OF CISPLATIN OR FLUOROURACIL IN COMBINED TREATMENT WITH (24R)-1,24-DIHYDROXYVITA- MIN D₃
46. FIRST ROUND STUDIES ON LEWIS LUNG CARCINOMA ACTIVITY OF THE NEW LEAD STRUCTURES IN THE ISOXAZOLE HETEROCYCLIC SYSTEM
47. GENISTEIN, ITS NEW ANALOGS AND COMPLEXES - THE ANTIPROLIFERATIVE EFFECTS ON HL-60 LEUKEMIA CELL LINE
48. COMBINATION OF: IMATINIB, PRI-2191 AND CYTOSTATICS - THE ANTIPROLIFERATIVE EFFECTS ON HL-60 LEUKEMIA CELL LINE
49. ANTIPROLIFERATIVE ACTIVITY IN VITRO OF DIASTEREOMERIC ANALOGUES OF VITAMIN D3 AGAINST NORMAL AND CANCER CELL LINES