Since many years, alkaloids such as ellipticine 1 and olivacine 2, are known of theirs antitumor activity.

They have inspired many groups of researchers to modify their chemical structure in the aim of improving the therapeutic index. Many of obtained compounds exhibited stronger antiproliferative activity then alkaloids mentioned above. Our investigations was concerned with modification the olivacine structure. One of derivatives we obtained 3 has entered II phase of clinical trials. Its analogues 4 also displayed strong activity against L1210. This prompted us to undertake a study on the synthesis of the title compound 5.

Cytotoxic activity of some compounds was performed in the Institute Curie (FRANCE) (for L-1210) and Institute of Immunology and Experimental Therapy (POLAND)(for A-549 lung cancer).

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1. Synthesis and anti-proliferative activity of selected aromatic bis(aminomethylidenebisphosphonic) acids
2. Biological activity of naphthyl-1,5-diamino-bis (methylidenebisphosphonic) acid – a new bisphosphonate
3. New acetylenic derivatives of betulin with anticancer activity
4. New calcipotriol analogs, their toxicity and antitumor activity in vivo in comparison to the affinity with VDR and DBP
5. Synthesis and cytostatic activity of new 1-substituted 6H-pyrido[4,3-b]carbazole derivatives
6. Influence of Transformation of the Amino Group in Anthracyclines into -N=CH-N< or -N=CH-O- Group on Their Biological Properties
7. PRIMARY CYTOTOXICITY EVALUATION OF NEW HETEROCYCLIC SYSTEMS WITH PYRIDODIAZEPINE.
8. CONJUGATED LINOLEIC ACIDS PREPARATIONS AS EFFECTIVE NUTRACEUTICS
9. THE ANTIMETASTATIC EFFECT OF BACTERIOPHAGE T4* ADMINISTRATED IN COMBINED TREATMENT WITH SELECTED CYTOSTATICS IN MICE WITH B16 MELANOMA
10. ANTITUMOR EFFECT OF CISPLATIN OR FLUOROURACIL IN COMBINED TREATMENT WITH (24R)-1,24-DIHYDROXYVITA- MIN D₃
11. CONJUGATES OF METHOTREXATE AND DEXTRANS IN MOUSE LEUKEMIA MODEL WITH MULTIPLE DOSE SCHEDULE
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13. DICARBOXYLATOPLATINUM(II) COMPLEX - SIX TIMES LESS TOXIC THAN CARBOPLATIN
14. ANTIPROLIFERATIVE ACTIVITY IN VITRO OF DIASTEREOMERIC ANALOGUES OF VITAMIN D3 AGAINST NORMAL AND CANCER CELL LINES