A series of alpha-asarone analogs were synthesized and tested for hypolipidemic activity (against Clofibrate as a reference drug) in male and female rats. Compounds 5-((1E)-but-1-enyl)-1,2,3-trimethoxybenzene (7), 5-((1E)-okt-1-enyl)-1,2,3-trimethoxybenzene (11), 2,6-dimethoxy-4-[(1E)-prop-1-enyl]phenyl nicotinate (21), 2,6-dimethoxy-4-[(1E)-pent-1-enyl]phenyl nicotinate (22) and {2,6-dimethoxy-4-[(1E)-pent-1-enyl]phenoxy}-4-oxobutanoic acid (24) reduced the total cholesterol, LDL cholesterol and increased the HDL cholesterol in male rats. Furthermore, compounds (11), (22) and (24) decreased triglyceride levels. Interestingly, compound (22) reduced the total cholesterol, LDL cholesterol and increased the HDL cholesterol also in female population. Thus, compound (22) 2,6-dimethoxy-4-[(1E)-pent-1-enyl]phenyl nicotinate may be considered as a good candidate for effective hypolipidemic drug. QSAR studies were conducted to examine the influence of structural properties on the compounds hypolipidemic activity.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/7038 must be provided.

1. Serotonin transporter inhibitors inducing hypothermia at mice
2. New analog of sulforaphane: 2-oxoheptyl isothiocyanate  as a compound with selective effect on the normal and colon cancer cells.
3. Ligand-directed receptor trafficking
4. Comparison of combined effects of 5-fluorouracil and allysin after concurrent treatment in colon and breast cancer cell lines
5. Synthesis of trans-4-cyclohexyl-(S)-proline - an intermediate in Fosinopril process
6. Application of Corona detector for analysis of 4-cyclohexyl-(S)-proline – key intermediate in Fosinopril synthesis
7. Sulforaphane modulates MRP expression and activity in Caco-2 cells
8. Proapoptotic effects of new pentabromobenzylisothioureas and CK2 inhibitor in prostate adenocarcinoma cell line
9. The combined effect of 5-fluorouracil and sulforaphane in prostate cancer cell line
10. Formation of Caco-2 monolayer - model for the prediction of intestinal drug absorption; method validation.
11. Application of amylose tris(3,5dimethylphenyl- carbamate) chiral stationary phase for the determination of paroxetine, clinically used psychotropic drug
12. Application of silica-bonded ovomucoin protein chiral stationary phase for the determination of paroxetine, clinically used psychotropic drug
13. Anti-oxidativeproperties of prenylflavonoids isolated from hops (Humulus lupulus L.)
14. Research on isolation and identification of cyclolinopeptides from waste products of the flax linseed (Linum usitatissimum L.)
15. Improvement of the Phase-Transfer Catalysis (PTC) method for synthesis of L-proline derivatives
16. Homology modeling of G-protein coupled receptors
17. Direct enantiomeric resolution of tamsulosin, clinically used chiral O-phenylethanolamine derivative with α₁-blocking activity
18. Application of carbohydrate based chiral stationary phase for resolution of  fenoterol, clinically used chiral drug
19. Identification of Novel 5-HT₇R Ligands via Multistep Virtual Screening of Commercially Available Compounds Databases
20. Alkyl-nitroquipazine derivatives as serotonin transporter and 5-HT_1A receptor ligands
21. Molecular dynamics of ligand binding and concurrent activation steps in opioid receptors
22. CHO cell line with stable expression of the HTRA1 gene as a tool for studying functional activity of 5-HT_1A receptor ligands
23. Synthesis and proapoptotic properties of new casein kinase II inhibitors
24. Non-cytotoxic small Carbon Nano-Onions - the first covalent functionalization with biomolecules
25. Determination of the enantiomeric purity of epinephrine in pharmaceutical preparations
26. Determination of the enantiomeric purity of norepinephrine in pharmaceutical preparations
27. Separation of enantiomers of Z and E 3-phenylglycidic acid t-butyl ester
28. Isolation and purification of (2R,3S)-3-phenylisoserine hydrochloride
29. Crystal structure of β-adrenergic receptor as a new template in homology modeling of GPCR. Application to serotonin 5-HT_1A and 5-HT₇ receptors
30. The ligand binding to the serotonin transporter
31. ANALYTICAL DETERMINATION OF HOMOCYSTEINE AND RELATED AMINOTHIOLS IN HUMAN PLASMA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH UV DETECTION
32. SYNTHESIS AND AFFINITY FOR SEROTONIN RECEPTOR 5HT_1A AND SEROTONIN TRANSPORTER OF SOME 6-NITROQUIPAZINE ANALOGUES.
33. COMPARISON OF THE STABILITY OF 5-AMINOLEVULINIC ACID AND HIS ESTERS
34. THE INFLUENCE OF TEMPERATURE AND SOLVENT ON DARZENS CONDENSATION STEREOSELECTIVITY
35. APPLICATION OF HPLC FOR ANALYTICAL CONTROL OF LARGE SCALE SYNTHESIS OF (2R, 3S)-3-PHENYLISOSERINE HYDROCHLORIDE
36. MOBILE PHASE INFLUENCE ON CHROMATOGRAPHIC BEHAVIOUR OF SOME 1,4-DISUBSTITUTED PIPERAZINES
37. ENANTIOSELECTIVITIES OF SOME 1,4-DISUBSTITUTED PIPERAZINES ON AMYLOSE CARBAMATE