trans-4-Cyclohexyl-(S)-proline, 1 is a crucial intermediate in the synthesis of Fosinopril 2 - prodrug used in the treatment of hypertension and acute or chronic congestive heart failure.

In a patent literature [1-3] three methods of synthesis of 1 are described, all of them are multistep process, requiring strictly anhydrous conditions, low temperature and tedious separation procedures.

We proposed and elaborated and original scheme of synthesis or 1, based on available cyclohexane carboaldehyde and ethyl 2-oxopropanoate [4].

Details of this synthesis will be discussed.

1.        Patent USA 4 316 905 (1982).

2.        Patent USA 4 588 819 (1986).

3.        Patent USA 4 734 508 (1988).

4.        Zgł. pat. P-392 283 (2010).

Praca realizowana w ramach projektu badawczego własnego nr N N209 237336 finansowanego przez Ministerstwo Nauki i Szkolnictwa Wyższego.

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