5-Aminolevulinic acid (ALA) I is commonly used in photodynamic therapy (PDT) and photodiagnosis (PD). Applied exogenously it is selectively metabolised in neoplastic tissues to yield actual photosensitizer: protoporphyrin IX (PpIX). The compound under light irradiation in reaction with molecular oxygen dissolved in tissue environment gives singlet oxygen responsible for necrosis of tumour tissues.

5-Aminolevulinic acid is used for therapy of skin diseases: Bowen's disease, basal cell carcinoma (BCC), acne; is also used for therapy and diagnosis of bladder, lungs and stomach tumours, in gyneacology and laryngology.

ALA has limited stability. The compoud in aqueous solution at physiological pH condenses to yield dihydropyrazine (II) and pyrazine (III) derivatives. The rate of the condensation is dependent on concentration of compound, temperature and pH value. Scheme of the reacion is shown below.

The aim of the work was comparison of the stability of ALA and chosen esters: methyl, ethyl, butyl and hexyl at different pH values (5,0; 5,5; 6,3 and 7,2). Concentration of 5-aminolevulinic acid and esters at time was determined by HPLC method.

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