Chromatographic behaviour of several 1,4-disubstituted piperazine derivatives on cellulose and amylose chiral stationary phases as well as mobile phase influence on solute-stationary phase complexes have been examined. The influence of hydrophobic aliphatic substituents appeared to be much stronger on cellulose than on amylose phase. Also mobile phase influence exhibited pronounced differences. For isopropanol-hexane mobile phases higher solute-stationary phase complex stabilities on cellulose than on amylase stationary phase were observed. On the other hand, on cellulose stationary phase in isopropanol-hexane mixtures the complex stabilities were bigger than in ethanol-hexane mixtures, while on amylose different relationship was observed. The significance of the obtained results will be discussed.

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