The increasing resistance of bacteria to currently available antibiotics necessitates every effort to develop novel antibacterial agents with lower rates of resistance. Amphipathic cationic dendrimers have been proposed as potential new class of antimicrobial agents, which are analogs of natural antimicrobial peptides (AMPs).

According to literature, incorporation of D-isomers alongside L-isomers in previously toxic AMPs reduce their toxicity without reducing their antimicrobial activity. The aim of this study was to examine the influence of introducing D- amino acid residues into dendrimeric molecules on their biological properties.

Therefore, we synthesized a series of dendrimers based on highly tetrabranched amino acid core with lipophilic C-terminus and arms terminated by L- or D-Trp residues. Their potency against Gram(-) and Gram(+) bacteria and their hemolytic activity was studied. The designed compounds were also evaluated for their antiproliferative activity against human melanoma cells.

Financial support from the National Center for Research and Development, grant NR13-0153-10/2010 and in part grant N204 239436 from the Ministry of Sciences and Higher Education,  is acknowledged.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/26407 must be provided.

1. Sex differences in the opioid component of swim stress-induced analgesia in mouse lines selected for high or low sensitivity to stress
2. Efficacy of Viburnum opulus fruit juice and its components against herpesvirus
3. New analgesics with adjuvant anticancer properties.
4. Keratin Associeted Proteins as a New Type of Bandage for Wound Healing
5. Development of new multitarget GPCRs ligands (opioid agonist- tachykinin antagonist).
6. Anticancer properties of hair proteins digestive peptides
7. Novel amphiphilic dendrimers as antibacterial and antitumoral agents.
8. Supramolecular assembly and properties of dendrimeric peptide mimics
9. CLA derivatives as functional food compounds
10. Keratin associated proteins (KAPs) as a new biomaterials for applications in medicine and cosmetology
11. Natural compositions with antioxidative properties
12. Application of fermentation in protein hydrolysates utilisation 
13. Comparable antinociceptive effect of biphalin in mice selected for high and low swim stress-induced analgesia after blood-brain barrier disruption caused by hyperosmolar mannitol administration
14. Application of preparative HPLC for protected peptide purification
15. Design of novel peptide dendrimers: antimicrobial and anticancer activity
16. New tachykinin-opioid chimeric analogues as potential new analgesics
17. Spinal cord peptide epitopes ameliorate immunological reaction in  experimental allergic encephalomyelitis /eae/
18. Dendrimeric peptides with  affinity to opioid receptors - complexation properties
19. Basic low molecular dendrimeric peptides designed for better membrane recognition
20. Development of dendrimeric somatostatin analogues
21. H-Dmt-D-Lys-Phe-Phe-OH, a tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20, expresses high antinociception
22. Submerged cultivation of Streptomyces sp. 8812 in media containing different sources of nitrogen and carbon
23. Novel bioactive metabolites
24. Amphiphilic dendrimeric peptides as efficient broad spectrum antimicrobial agents
25. JS-1, a novel isoquinoline alkaloid with antimicrobial activity isolated from Streptomyces sp. 8812
26. Polyhydroxylated indolizidine and pyrrolizidine alkaloids. Synthesis and bioactivity.
27. THERMOSENSITIVE TRI-BLOCK-CO-POLY- MERS POLY- (HPMAm-MONO/DI LACTATE)- PEG-POLY(HPMAm-MONO/DI LACTATE) FOR THE CONTROLLED RELEASE OF OPIOID PEPTIDES
28. HYDROLISATE OF PIG SPINAL CORD AS A NUTRACEUTIC IN MULTIPLE SCLEROSIS.
29. KERATINE PREPARATIONS FOR WOUND HEALING
30. DEVELOPMENT OF NEW TACHYKININ-OPIOID CHIMERIC ANALOGUES AS POTENTIAL NEW ANALGESIC
31. OPIOID PEPTIDE ANALOGUE AA2016 IN MOUSE MODEL OF INDIVIDUAL PAIN SENSITIVITY
32. A SIMPLE PREPARATIVE HPLC ISOLATION OF CONJUGATED LINOLEIC ACIDS (CLAs).
33. NOVEL, BIOLOGICALLY ACTIVE INHIBITOR OF DD-PEPTIDASE 64-575.
34. SEARCH FOR NEW ANTIMICROBIAL PEPTIDES FROM HYDROLIZATES OF SEED PROTEINS.