It is widely appreciated among clinicians and researches that sensitivity to pain and responses to analgesics are highly variable. In the process of discovery of new analgesic this phenomena should be taken into account. However, tendency to eliminate of any individual variability is visible even in preliminary stages of selection of drug candidates using animal tests. Over twenty years ago Sadowski et al. developed genetic mouse lines selectively bred for high and for low swim stress-induced analgesia (SSIA). These animal lines may well simulate human high and low sensitivity to both, pain and stress response.This communication will present different response to opioid peptide analogue AA2016 by mouse SSIA without any stressor. The possible reasons of observed differences in analgesic effects will be discussed.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/6922 must be provided.

1. Sex differences in the opioid component of swim stress-induced analgesia in mouse lines selected for high or low sensitivity to stress
2. Neuroprotective effects of biphalin in a mouse model of mild traumatic brain injury (mTBI)
3. Efficacy of Viburnum opulus fruit juice and its components against herpesvirus
4. New analgesics with adjuvant anticancer properties.
5. Keratin Associeted Proteins as a New Type of Bandage for Wound Healing
6. Development of new multitarget GPCRs ligands (opioid agonist- tachykinin antagonist).
7. Anticancer properties of hair proteins digestive peptides
8. Effects D-tryptophan substitutions on the activity and toxicity of antimicrobial dendrimers
9. Novel amphiphilic dendrimers as antibacterial and antitumoral agents.
10. CLA derivatives as functional food compounds
11. Keratin associated proteins (KAPs) as a new biomaterials for applications in medicine and cosmetology
12. Natural compositions with antioxidative properties
13. Application of fermentation in protein hydrolysates utilisation 
14. Comparable antinociceptive effect of biphalin in mice selected for high and low swim stress-induced analgesia after blood-brain barrier disruption caused by hyperosmolar mannitol administration
15. Application of preparative HPLC for protected peptide purification
16. New tachykinin-opioid chimeric analogues as potential new analgesics
17. Spinal cord peptide epitopes ameliorate immunological reaction in  experimental allergic encephalomyelitis /eae/
18. Dendrimeric peptides with  affinity to opioid receptors - complexation properties
19. Development of dendrimeric somatostatin analogues
20. Assessment of analgesic potency of biphalin in a mouse model of cancer pain  
21. H-Dmt-D-Lys-Phe-Phe-OH, a tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20, expresses high antinociception
22. THERMOSENSITIVE TRI-BLOCK-CO-POLY- MERS POLY- (HPMAm-MONO/DI LACTATE)- PEG-POLY(HPMAm-MONO/DI LACTATE) FOR THE CONTROLLED RELEASE OF OPIOID PEPTIDES
23. HYDROLISATE OF PIG SPINAL CORD AS A NUTRACEUTIC IN MULTIPLE SCLEROSIS.
24. KERATINE PREPARATIONS FOR WOUND HEALING
25. DEVELOPMENT OF NEW TACHYKININ-OPIOID CHIMERIC ANALOGUES AS POTENTIAL NEW ANALGESIC
26. A SIMPLE PREPARATIVE HPLC ISOLATION OF CONJUGATED LINOLEIC ACIDS (CLAs).
27. SEARCH FOR NEW ANTIMICROBIAL PEPTIDES FROM HYDROLIZATES OF SEED PROTEINS.