The selected topics will be brought up in order to draw attention to the fact that the physical interaction between cell and scaffold is an important aspect of tissue engineering hybrid system consisting of a nonviable scaffold and living cells. Particularly, cell “feeling” of the support stiffness will be discussed on the basis of the recent scientific reports and the results from our group. Some attention will be paid to the new findings concerning mechanoreceptors of bone cells based on the patch-clamp methodology.

On the other hand, application of methods, which detect physical phenomena, to investigations of tissue organized inside the scaffold in vivo will be exemplified by a detection of bone formation in our tissue engineered product by means of the electron paramagnetic resonance (EPR).

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4. Culture of osteoblasts on nanostructured titanium – preliminary observation
5. Bone tissue engineered product based on human bone derived cells and polyurethane scaffold
6. Calcite-based material for tissue engineering ceramic scaffolds
7. Optimization of polyurethane structure as the potential materials for bone tissue engineering applications
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