An catalityc enzyme in the last part of glikolisis is LDH, lactase dehydrogenase[EC 1.1.1.27]. LDH is cytoplasmatic enzyme, marker of many chronic illuess: cardiopathy, hepatopathy, and new growth. The influence of doxorubicin on activity of lactase dehydrogenase, LDH, of squamous cell carcinoma (SCC) cells of the line AT478 from mous C3H was studies. The squamous cell carcinoma (SCC) is a special line of cell culture that has the ability for megacolonies creation growning in continous contract with ground and other cells. Our studies were carried out on six groups: 3 study groups, exposition for doxorubicine 24 h, and 3 study groups, exposition for doxorubicine 72h. In 2 control groups (24 and 72 h) the cells grew with out any influence of doxorubicine. The influence of doxorubicine on activity of lactase dehydrogenase, LDH, in cells medium was investigated. Our results suggest that doxorubicine, in used doses and time periods, influences the biochemical metabolism of squamous cell carcinoma in vitro.

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