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Vascular Cell Adhesion Molecule-1 as a risk factor of atherosclerosis in diabetes mellitus patients.

Ewa Romuk 1Jolanta Jagosz Bronisława Skrzep-Poloczek Krzysztof Strojek Ewa Birkner 

1. Śląska Akademia Medyczna Zakład Biochemii Ogólnej Katedry Biochemii (ŚAM), Jordana 19, Zabrze 41-808, Poland


Background: Diabetes Mellitus (DM) is the chronic disease that is associated with an increased risk of premature atherosclerosis. The “response to injury” hypothesis postulates that the initial step of atherogenesis is represented by endothelial dysfunction. The first sign of disease activity is an upregulation of adhesion molecules such as vascular cell adhesion molecule VCAM-1. The aim of our study was to evaluate the concentration of VCAM-1 in patients with diabetes mellitus.

Materials and methods: We have studied 20 patients with type I DM, 20 patients with type II DM and 20 healthly persons without DM. Total cholesterol, HDL -cholesterol, triglicerydes we have measured with the use of standard kits (Alpha Diagnostic, Poland), LDL-cholesterol was measured directly with the biomerieux kit (bioMerieux, France). Serum VCAM-1 concentration was measured by ELISA kit.(Biomedica, Niemcy).

Results: Concentration of VCAM-1 in DM II was statistically significant higher than in type I DM (918,55±280,23 ng/ml vs. 759,14±105,45 ng/ml, p<0,05). VCAM-1 concentration in type I DM and type II DM was statistically significant higher tan in control group (759,14±105,45 ng/ml vs. 595,61±198,23 ng/ml, p<0,05 and 918,55±280,23 ng/ml vs. 595,61±198,23 ng/ml, p<0,05). There were no changes in lipids parameters.

Conclusion: The present study demonstrated that in diabetes mellitus patients endothelial function is abnormal. Increased VCAM-1 concentration suggest that this molecule play an important role in the initiation of atherosclerosis.


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Presentation: Poster at Zjazd Polskiego Towarzystwa Biochemicznego, Sympozjum D, by Ewa Romuk
See On-line Journal of Zjazd Polskiego Towarzystwa Biochemicznego

Submitted: 2007-04-30 13:55
Revised:   2009-06-07 00:44