Protoporphyrine IX and its PEI derivatives as possible photosensitizer in antibacterial photodynamic therapy
|Ewa Rząd , Urszula Kwolek , Mariusz Kępczyński , Maria Nowakowska|
Jagiellonian University, Faculty of Chemistry, Ingardena 3, Kraków 30-060, Poland
The progressive increase in bacterial resistance to antibiotics makes it conducted a search for new treatments for bacterial infections. One of the new method is antibacterial photodynamic therapy. The possibility of its application depends on the availability of appropriate photosensitizers (PS), which will allow for efficient cell destruction of pathogens. Photosensitizers currently used in cancer therapy are generally not suitable for the treatment of bacterial infections. There is a particularly their ineffectiveness against infections caused by Gram (-). The main reason for this is specific to the construction of these pathogens. In contrast to Gram (+), they have an outer membrane composed primarily of lipopolysaccharides. It functions as an impermeable barrier (negatively charged), protecting against the effects of bacterial cells with a photosensitiser. Therefore, for effective treatment, it becomes necessary to use the PS are able to overcome this barrier, or early treatment of bacterial substances that destroy the structure of their outer membrane, such as EDTA or cationic polypeptides. An example of effective photosensitizers against both Gram (-) and Gram (+) proved to be conjugate of polyethyleneimine chlorin or chlorin with poly-L-lysine.
The present work is focused on attaching protoporphyrin (Pp) to the polymer chain (PEI).
Presentation: Poster at Nano-Biotechnologia PL, by Ewa Rząd
See On-line Journal of Nano-Biotechnologia PL
Submitted: 2012-06-30 21:56 Revised: 2012-06-30 21:57
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