Selective adsorbents of adenosine-5'-triphosphate

Anna M. Mikulska 1Shin-Ichi Yusa 2Krzysztof Szczubiałka 1Yotaro Morishima 3Maria Nowakowska 1

1. Uniwersytet Jagielloński, Wydział Chemii (UJ), Ingardena 3, Kraków 30-060, Poland
2. University of Fukui (U. Fukui), 3-9-1 Bunkyo, Fukui 910-8507, Japan
3. University of Hyogo, Graduate School of Material Science, Kohto, Kamigori, Hyogo 678-1297, Japan


The purpose of this studies was the synthesis and characterization of hybrid polymeric-inorganic materials which can be used for selective adsorption and sensing of adenine-containing compounds, in particular adenosine triphosphate (ATP), which is a biomarker for neutrophilic airway inflammation and ischemia and may have considerable potential in the management of ischemic heart disease and stroke.

Silica gel particles were coated with a polyanion bearing thymine chromophores. The polymer coated particles were found to selectively adsorb adenine and ATP, as compared to other nucleobases and nucleotides, respectively. The adsorption was enhanced by the irradiation of the particles in the presence of adenine which resulted in the molecular imprinting of adenine and improved selectivity vs. other nucleobases and nucleotides. It was found that ATP adsorption was strongly pH-dependent.




Acknowledgement: Financial support from National Science Centre, grant “Hybrid adsorbents and sensors of adenine-containing compounds” is gratefully acknowledged. Project financed in part within the Foundation for Polish Science Team Programme co-financed by the European Regional Development Fund, PolyMed, TEAM/2008-2/6.

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Presentation: Poster at Nano-Biotechnologia PL, by Anna M. Mikulska
See On-line Journal of Nano-Biotechnologia PL

Submitted: 2012-06-28 13:31
Revised:   2012-06-28 13:36
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