Properties of DODAB/oleyl alcohol and DODAB/cholesterol monolayers and bilayers

Karolina Witkowska ,  Mariusz Kępczyński ,  Paweł Wydro ,  Maria Nowakowska 

Jagiellonian University, Faculty of Chemistry, Ingardena 3, Kraków 30-060, Poland

Abstract

Recently, the nanoscopic vesicular structures have been the subject of considerable interest in  both: colloid and materials science. The application of liposomes is very wide and includes medicine, cosmetology, environment protection, health food formulation and production, science etc.[1] However, the high price of natural lipids strongly limits the application of liposomes. That is why it is reasonable to investigate vesicles formed with double-tailed surfactants such as dioctadecyldimethylammonium bromide (DODAB). Unfortunately, the structures of formed vesicles were nonspherical.[2]

To improve the morphology of obtain objects the additions of oleyl alcohol and cholesterol were applied. Oleyl alcohol as the compounds possessing cis double bond in the chain forms liquid monolayers and therefore it can be expected that the incorporation of oleyl alcohol molecules should have strongly fluidizing influence on DODAB monolayer. The effect of cholesterol on membranes is in turn rather complex. Generally cholesterol reduces the fluidity of bilayers and monolayers but the addition of small amount of this sterol to dialkyldimethylammonium bromides monolayers may also cause an increase of their fluidity.[3]

It is suggested that at the surface pressures between 30 and 35 mN/m the monolayer properties, such as area per molecule, lateral pressure and elastic compressibility modulus, correspond to the properties of bilayer[4],[5] that is why in this work Langmuir monolayer measurements of the DODAB/oleyl alcohol and DODAB/cholesterol mixtures were performed.

References:

[1] D. D. Lasic; Handbook of Biological Physics, chapter 10: Applications of Liposomes, Elsevier Science B.V., California, 1995

[2] M. Kepczynski, J. Lewandowska, K. Witkowska, S. Kędracka-Krok, V. Mistrikova, J. Bednar, P. Wydro, M. Nowakowska; Chemistry and Physics of Lipids, 2011, 164, 359

[3] K. Hąc-Wydro, P. Wydro, P. Dynarowicz-Łątka; Journal of Colloid and Interface Science, 2005, 286, 504

[4] D. Marsh; Biochim. Biophys. Acta, 1996, 1286, 183

[5] J. F. Nagle, S. Tristram-Nagle; Biochim. Biophys. Acta, 2000, 1469, 159

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Presentation: Poster at SMCBS'2011 International Workshop, by Karolina Witkowska
See On-line Journal of SMCBS'2011 International Workshop

Submitted: 2011-10-07 12:27
Revised:   2011-10-07 12:27
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