Recently, the nanoscopic vesicular structures have been the subject of considerable interest in  both: colloid and materials science. The application of liposomes is very wide and includes medicine, cosmetology, environment protection, health food formulation and production, science etc.^[1] However, the high price of natural lipids strongly limits the application of liposomes. That is why it is reasonable to investigate vesicles formed with double-tailed surfactants such as dioctadecyldimethylammonium bromide (DODAB). Unfortunately, the structures of formed vesicles were nonspherical.^[2]

To improve the morphology of obtain objects the additions of oleyl alcohol and cholesterol were applied. Oleyl alcohol as the compounds possessing cis double bond in the chain forms liquid monolayers and therefore it can be expected that the incorporation of oleyl alcohol molecules should have strongly fluidizing influence on DODAB monolayer. The effect of cholesterol on membranes is in turn rather complex. Generally cholesterol reduces the fluidity of bilayers and monolayers but the addition of small amount of this sterol to dialkyldimethylammonium bromides monolayers may also cause an increase of their fluidity.^[3]

It is suggested that at the surface pressures between 30 and 35 mN/m the monolayer properties, such as area per molecule, lateral pressure and elastic compressibility modulus, correspond to the properties of bilayer^[4],[5] that is why in this work Langmuir monolayer measurements of the DODAB/oleyl alcohol and DODAB/cholesterol mixtures were performed.

References:

[1] D. D. Lasic; Handbook of Biological Physics, chapter 10: Applications of Liposomes, Elsevier Science B.V., California, 1995

[2] M. Kepczynski, J. Lewandowska, K. Witkowska, S. Kędracka-Krok, V. Mistrikova, J. Bednar, P. Wydro, M. Nowakowska; Chemistry and Physics of Lipids, 2011, 164, 359

[3] K. Hąc-Wydro, P. Wydro, P. Dynarowicz-Łątka; Journal of Colloid and Interface Science, 2005, 286, 504

[4] D. Marsh; Biochim. Biophys. Acta, 1996, 1286, 183

[5] J. F. Nagle, S. Tristram-Nagle; Biochim. Biophys. Acta, 2000, 1469, 159

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/25135 must be provided.

1. Nano/micro drug carriers
2. Studies on the inhibition mechanism of the human coronavirus NL63 replication by polycations
3. Polisacharydowo-białkowe membrany do rekonstrukcji rogówki
4. Protoporphyrine IX and its PEI derivatives as possible photosensitizer in antibacterial photodynamic therapy
5. Albumin-HMchitosanGTMAC-based nanoparticles as potential controlled release delivery systems of curcumin
6. Novel nanostructural photosensitizers for photodynamic therapy
7. Selective adsorbents of adenosine-5'-triphosphate
8. Novel polymeric inhibitors of human coronavirus NL63
9. Superparamagnetyczne nanocząstki tlenku żelaza opłaszczane pochodnymi chitozanu – nowe kontrasty do MRI
10. Polymeric Nanocapsules for Controlled Delivery of Lipophilic Drugs
11. Dextran-based materials reducing anticoagulant activity of heparin in animal models in vitro and in vivo
12. Preliminary studies on a new way of nucleic acids extraction using hydrogel microsphere
13. Synthesis and physicochemical properties of cationic chitosan derivative for heparin complexation
14. Cationic chitosan derivative for heparin reversal - in vitro and in vivo studies in rats