The aim of our study was todetermine the impact of different concentrations of 6-hydroxyhexanoic acid on human fibroblasts (HGF-1 cell line). Changes in cell morphology and growth rate were analyzed as well as the concentration of tested compound in cell culture medium was assessed.

6-hydroxyhexanoic acid was used at a concentrations range of 0,1–20 mM. Cell proliferation was measured using sulforhodamine B, a dye binding to cellular proteins. Concentration of the studied compound in culture medium was assessed using HPLC technique.

Fibroblasts growing in the presence of6-hydroxyhexanoic acid at all concentrations displayed normal morphology, remained spread on the substratum and any cell detachment was not observed. Some inhibition of cell growth was seen exclusively at the highest concentration of the tested substance.

Generally, results of our study evidence the biocompatibility of the degradation product of poly-ε-caprolactone.

Acknowledgement: This study has been financially supported by MEMSTENT (Grant No: UDA-POIG.01.03.01-00-123/08-01).

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/22998 must be provided.

1. Effects of 300 mT static magnetic field on IL-8 secretion in normal human colon myofibroblasts
2. Study on the model of risperidone release from poly(L-lactide-co-glycolide) (85:15) matrices
3. Influence of structural and surface properties on the release of risperidone from poly(D,L-lactide-co-glycolide) (70:30) matrices
4. Effect of the degradation of poly(L-lactide-co-glycolide) (85:15) matrices containing risperidone on thermal and morphological properties
5. Degradation process of L-lactide/glycolide/trimethylene carbonate terpolymer in cell culture environment
6. Histone H3 expression – a potential cell proliferation marker for molecular pharmacology
7. Bioresorbable copolymer of L-lactide and ε-caprolactone for controlled paclitaxel delivery 
8. Effect of Gly-His-Lys and its copper complex on TGF-β1 secretion in normal human dermal fibroblasts
9. The effect of sulphasalazine and 5-aminosalicylic acid on the human colon myofibroblasts
10. Antiproliferative activity of novel acetylenic derivatives of betulin against G-361 human melanoma cells
11. Synergistic antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells
12. Polyunsaturated fatty acids potentate cytotoxicity of cisplatin in A549 cells
13. Antiproliferative and apoptotic effects of valproic acid in human melanoma cells
14. Phytic acid down-regulates IL-8 secretion from IL-1β stimulated colonic epithelial cells by influencing mitogen-activated protein kinase signaling pathway.
15. Comparison of dissolution profiles of theophylline extended-release dosage forms
16. The effects of 300 mT static magnetic field on IL-6 secretion in normal human colon myofibroblasts
17. Effect of valproic acid and cisplatin on the proliferation of tumor cell lines A375 and C32
18. Examination of free radicals in melanins isolated from A-375 cells exposed on valproic acid and cisplatin by EPR spectroscopy
19. Polyunsaturated fatty acids inhibit melanoma cell growth in vitro
20. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on the TNF-α – dependent IL-6 secretion in normal human dermal fibroblasts
21. Evaluation of proliferation and cellular death of A375 cell line in the presence of HDACs inhibitors
22. Influence of troglitazone, sodium butyrate and 5-aminosalicylic acid on the chemokine ENA-78/CXCL5 secretion in the intestinal subepithelial myofibroblasts
23. Comparison of accelerated and real-time cyclosporine A release testing from poly(L-lactide-co-trimethylene carbonate) matrices
24. The influence of paclitaxel on hydrolytic degradation process in matrices obtained from aliphatic polyesters and polyestercarbonates
25. Polyunsaturated fatty acids alter expression of genes encoding antioxidant enzymes in A549 cells exposed to doxorubicin
26. Chemical characteristics of melanin from the human melanoma malignum
27. The thermochemolysis of melanins isolated from melanoma malignum
28. The degree of substitution of Desulfovibrio desulfuricans lipopolysaccharides and their lipid A component by phosphates
29. GROWTH OF HUMAN CHONDROCYTES ON BIODEGRADABLE SYNTHETIC POLYMERS
30. INFLUENCE OF SODIUM BUTYRATE ON ANTIOXIDATIVE ENZYMES ACTIVITY IN CACO-2 CELL LINES.
31. ANTI-PROLIFERATIVE EFFECTS OF INOSITOL HEXAPHOSPHATE AND VERAPAMIL ON HUMAN COLON CANCER CACO-2 AND HT-29 CELLS
32. LONG-TERM CYCLOSPORINE A (CyA) AND SIROLIMUS RELEASE FROM BIODEGRADABLE MATRICES AS A RESULT OF OPTIMAL ADJUSTMENT OF COPOLYMER CHAIN MICROSTRUCTURE