Dissolution testing has emerged in the pharmaceutical field as a very important tool to characterize drug product performance, for example, to demonstrate similarity between different formulations. Because the rate of release of theophylline could differ between the products, the patient health may be endangered, especially that this drug has a narrow therapeutic range.

The investigation of theophylline release from tablets was performed by the basket apparatus type DT700 (Erweka). The f1 (difference factor) and f2 (similarity factor), calculated according to FDA guidelines, were used to compare the obtained dissolution profiles, using Euphyllin long 300 as a reference product.

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