Bioresorbable, aliphatic polyesters are known in medicine where serve as orthopedic devices (e.g. rods, pins and screws) or sutures and staples in wound closure. Moreover, such materials are extensively studied as scaffolds – three-dimensional structures for tissue engineering but also drug delivery systems (DDS) [1].

The aim of this study was to determine release profile of paclitaxel, one of the anti-inflammatory, antiproliferative and anti-restenotic agent [2], from biocompatible copolymer based on L-lactide and ε-caprolactone that seems to be very attractive especially for minimally invasive surgery due to its potential shape-memory property. The influence of drug on copolymer hydrolytic degradation was also analyzed.

Three types of matrices (3%, 5% of PTX and without drug) were prepared by solvent-casting method and degraded in vitro. The physicochemical changes of copolymer were analyzed by means of nuclear magnetic resonance spectroscopy (NMR), gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). The amount of drug released into media was monitored with the use of high-pressure liquid chromatography (HPLC). Similar drug release profiles were obtained for matrices with paclitaxel. The drug-containing matrices degraded slightly slower than drug free matrices, regardless PTX content.

Results of this work may be helpful in designing new bioresorbable paclitaxel delivery system applied in anti-cancer therapy or drug-eluting stents technology.

Acknowledgement:

This study has been financially supported by a Grant from Polish Ministry of Science and Higher Education (N N405 682 340) and Centre of Polymer and Carbon Materials (Grant for Young Scientists 2013).

References:

[1] Ulery BD, Nair LS, Laurencin CT. Biomedical Applications of Biodegradable polymers. J Polym Sci B Polym Phys 2011; 49: 832–864.

[2] Martin DM, Boyle FJ. Drug-eluting stents for coronary artery disease: A review. Med Eng Phys 2011; 33: 148-163.

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