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FIA detection of nicotine and cotinine using piezomicrogravimetric sensors with zinc porphyrin polymer films as their recognition elements

Krzysztof R. Noworyta 1Wlodzimierz Kutner 1,2Channa A. Wijesinghe 3Serge G. Srour 3Francis D'Souza 3

1. Polish Academy of Sciences, Institute of Physical Chemistry, Kasprzaka 52/56, Warszawa 01-224, Poland
2. Cardinal Stefan Wyszynski University, Faculty of Mathematics and Natural Sciences, Dewajtis 5, Warszawa 01815, Poland
3. Wichita State University, Department of Chemistry, 1845, Fairmount, Wichita, KS 67260-0051, United States


  Thin films of zinc porphyrin polymers with one or two acetamide “arms” deposited on electrodes by electrochemical polymerization were used as recognition elements of a piezomicrogravimetric chemosensor for determination of nicotine and its metabolite – cotinine under FIA conditions.  Morphology as well as spectral and electrochemical properties of the films was studied.  Subsequently, the polymer films deposited on quartz crystal resonators were employed as recognition elements of a piezomicrogravimetric chemosensor for determination of nicotine and cotinine.  Spectral results indicated that the porphyrin macrocycles remain essentially intact during electropolymerization for both porphyrin monomers used, which is a prerequisite for successful polymer application as the recognition element in the chemosensor.  AFM imaging as well as spectral and electrochemical studies point to differences in morphology, porosity and cross-linking between polymer films formed from the monomer bearing two and one acetamide arm.  More open structure of the former polymer film was also reflected by higher sensitivity towards nicotine as compared to that of the chemosensor coated by the latter film.  FIA studies of the (porphyrin polymer)-resonators allowed for determination of adsorption and desorption rate constants of the studied analytes in the polymers as well as stability constants of the (zinc porphyrin polymer)-analyte complexes.  Analytical parameters of the newly devised chemosensor were also evaluated.


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Presentation: Short communication at SMCBS'2009 International Workshop, by Krzysztof R. Noworyta
See On-line Journal of SMCBS'2009 International Workshop

Submitted: 2009-09-15 15:03
Revised:   2009-09-15 17:02