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Possible biotechnology applications of seed mediated grown gold nanorods

Filip Novotny 1Anton Fojtík 1Michael Giersig 2

1. Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering, Department of Physical Electronics, Brehova str. 7, Prague 115 19, Czech Republic
2. Helmholtz Centre Berlin for Materials and Energy, Glienicker Str. 100, Berlin D-14109, Germany

Abstract

Gold nanorods (GNR) are very promising material due to the appearance of localized surface plasmon resonance (LSPR). The LSPR is splitted into two modes where the frequency of the longitudal one is strongly dependent on the rod aspect ratio. Therefore one can tune the optical properties of sample by controlling the aspect ratio of the rods. As the gold nanomaterials also exhibit good chemical stability under various conditions and biocompatibility, they are interesting candidate for bioconjungation and usage in biological systems.

During past decades a number of methods of gold nanorod synthesis was explored and some of them were refined to the point, where one can grow large volumes of high yield samples directly in solution. Such colloidal aqueous solution is very convenient for further biofunctionalization. One of such methods, which is used in this work, is seed mediated growth of gold rods from monocrystalline spherical gold seeds using a specific surfactant.

Samples are studied by the means of absorption spectroscopy of LSPR bands and TEM imaging. Several experiments of covering the GNRs with thiol-like organic substances were conducted and the effect of adsorbed biologic material to the LSPR is discussed. An improvement of the nanorods growth process and yield is proposed by controlling the acidicity of the growth solution.

Such colloidal material can then be used for number of biomedicine and biotechnology applications including targeted drug delivery (TDD) and surface enhanced raman spectroscopy (SERS), which will be discussed in detail.

 

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Related papers

Presentation: Oral at E-MRS Fall Meeting 2008, Symposium E, by Filip Novotny
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-05-26 15:14
Revised:   2009-06-07 00:48