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Biomedical Application of Metallic and Magnetic Nanoparticles |
Anton Fojtík |
Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering, Department of Physical Electronics, Brehova str. 7, Prague 115 19, Czech Republic |
Abstract |
Nanotechnology is getting still more attention and is becoming emerging topic of recent days. Its biological and medical approaches and applications are opening novel, unpredicted and efficient ways of solving health issues, that is why the extraordinary field of bionanotechnology is shaping into one of the leading sciences of the 21st century… Goal of the project is to functionalize Fe3O4 magnetic nanoparticles, which according to chemical groups attached at the surface, are able to bond to special pathogens (bacteria or virus) and being easily manipulated by magnetic field, they can be removed from the system taking the pathogens with them as well. Nanoparticles are produced by 'wet' chemical way under special conditions. Final product is 10s of nanometers in diameter and possesses special superparamagnetic properties, which give it ability to be manipulated while working in complex biological systems such as human body. Shape and size of nanoparticles are evaluated using AFM, magnetic properties measured by Mössbauer Spectroscopy and Superconducting Quantum Interference Device (SQUID). Surface of the particles is stabilized and treated, so that they maintain their unique properties and remain stable and separated. Certain chemical groups, proteins or residues are attached onto the surface to functionalize it. Particles are then ready to play a key role in recognition of the pathogens bonding to the surface of nanoparticles and following applied magnetic field to get out of the system. |
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Presentation: Keynote lecture at E-MRS Fall Meeting 2008, Symposium E, by Anton FojtíkSee On-line Journal of E-MRS Fall Meeting 2008 Submitted: 2008-05-19 18:38 Revised: 2009-06-07 00:48 |