Skin protein structure reconstruction is one of the major factors of skin healing when injured by accidents, suffered by infection or disease degeneration (e.g. diabetes). Unfortunately, the healing processes are very slow. To enhance the healing processes we developed KAP's preparations, which added to healing space, could be easily colonized by migrated epithelial cells. We predicted that KAP's structures should be highly complementary to proliferated cells in the wound and to their keratins. To test this approach we adopted diabetic rodent model for studies of wound healing processes.  In this model we tested histology of wound healing processes with or without keratin preparation applied. Mouse fur or human hairs were primary sources of keratin preparations. Developed keratin preparations were characterized by lack of immunogenicity that is the independent from the original source. Keratin dressing has been adsorbed in regenerating tissue during healing process, which eliminates painful and risky stages of dressing replacement. The preliminary animal in vivo results confirm that obtained keratin powders could be used as a part of wound dressing that will be adsorbed in regenerating skin during healing process.

Acknowledgement:

This work was supported by the Polish National Science Center (NCN), 2011/01/B/ST5/07818 as well as Mazowian Peptide Cluster.

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