The group of flavonilignans so called silymarin is known as a medicine for liver treatment but it also has anticancer and antioxidant properties.

Silymarin is usually obtained from the milk thistle  seed husk (Silibum marianum). The post process milk thistle endosperm contains less flavonolignans than husk and a lot of oil (20-30%) which complicates procedure of silymarin isolation.

As a result of ethyl alcohol extraction from the milk thistle endosperm, two fractions were obtained: raw oil fraction and solid fraction that contained silymarin (30-35%), phospholipids (1,2-1,6%) and oil (10-20%) with 80% unsaturated fatty acids. Antioxidant properties of the solid fraction, pure silymarin and derivative of vit. C were tested on Rancimat 679.

            Rape seed oil were tested with addition of antioxidants:

-6-O-Palmitoyl-L-ascorbic acid,

-solid fraction of milk thistle endosperm,

-pure silymarin,

-mixtures of listed above compounds.

Comparing results it was observed that:

-6-O-Palmitoyl-L-ascorbic acid i better antioxidant than solid fraction of endosperm of milk thistle,

-solid fraction of milk thistle endosperm should be used in amount bigger than 0,2%

-applying mixture of two above antioxidants gives better results

-solid fraction of milk thistle endosperm is better antioxidant than pure silymarin

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/23045 must be provided.

1. Sex differences in the opioid component of swim stress-induced analgesia in mouse lines selected for high or low sensitivity to stress
2. Efficacy of Viburnum opulus fruit juice and its components against herpesvirus
3. New analgesics with adjuvant anticancer properties.
4. Keratin Associeted Proteins as a New Type of Bandage for Wound Healing
5. Development of new multitarget GPCRs ligands (opioid agonist- tachykinin antagonist).
6. Anticancer properties of hair proteins digestive peptides
7. Effects D-tryptophan substitutions on the activity and toxicity of antimicrobial dendrimers
8. Novel amphiphilic dendrimers as antibacterial and antitumoral agents.
9. CLA derivatives as functional food compounds
10. Keratin associated proteins (KAPs) as a new biomaterials for applications in medicine and cosmetology
11. Anti-oxidativeproperties of prenylflavonoids isolated from hops (Humulus lupulus L.)
12. Application of fermentation in protein hydrolysates utilisation 
13. Comparable antinociceptive effect of biphalin in mice selected for high and low swim stress-induced analgesia after blood-brain barrier disruption caused by hyperosmolar mannitol administration
14. Application of preparative HPLC for protected peptide purification
15. New tachykinin-opioid chimeric analogues as potential new analgesics
16. Spinal cord peptide epitopes ameliorate immunological reaction in  experimental allergic encephalomyelitis /eae/
17. Dendrimeric peptides with  affinity to opioid receptors - complexation properties
18. Development of dendrimeric somatostatin analogues
19. H-Dmt-D-Lys-Phe-Phe-OH, a tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20, expresses high antinociception
20. THERMOSENSITIVE TRI-BLOCK-CO-POLY- MERS POLY- (HPMAm-MONO/DI LACTATE)- PEG-POLY(HPMAm-MONO/DI LACTATE) FOR THE CONTROLLED RELEASE OF OPIOID PEPTIDES
21. HYDROLISATE OF PIG SPINAL CORD AS A NUTRACEUTIC IN MULTIPLE SCLEROSIS.
22. KERATINE PREPARATIONS FOR WOUND HEALING
23. DEVELOPMENT OF NEW TACHYKININ-OPIOID CHIMERIC ANALOGUES AS POTENTIAL NEW ANALGESIC
24. OPIOID PEPTIDE ANALOGUE AA2016 IN MOUSE MODEL OF INDIVIDUAL PAIN SENSITIVITY
25. A SIMPLE PREPARATIVE HPLC ISOLATION OF CONJUGATED LINOLEIC ACIDS (CLAs).
26. SEARCH FOR NEW ANTIMICROBIAL PEPTIDES FROM HYDROLIZATES OF SEED PROTEINS.