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Keratin associated proteins (KAPs) as a new biomaterials for applications in medicine and cosmetology

Andrzej W. Lipkowski 1,3Katarzyna Kurzepa 3Anna Grabowska 2,3Aleksandra M. Szczucińska 3Barbara Gajkowska 1,3Marcin Jurga 1Marta Bochynska 1,3Katarzyna Michalec 1,3

1. Polska Akademia Nauk, Instytut Medycyny Doświadczalnej i Klinicznej (PAN), Warszawa, Poland
2. Instytut Chemii Przemysłowej (IChP), Rydygiera 8, Warszawa 01-793, Poland
3. Polish Scientific Network of Medicinal Chemistry of Peptides, Pawinskiego 5, Warsaw 02106, Poland

Abstract

Micro- and  nanobiotechnology are the most explored fields in contemporary life science. This stimulates development of new 3D structural synthetic and semisynthetic materials. Usually, application of proteins as structural biopolymers requires chemical modifications resulting in increased stability of their 3D structures. The biocompatibility of these materials is the most important problem. Our team developed new technology of producing keratin associated protein (KAP) scaffolds from hair, wool and bristle.     

Hair keratin associated proteins (hKAP), as well as other biomaterials of this type, are essential for the formation of a rigid and resistant hair shaft. Rigid structures are obtained due to extensive disulfide bond cross-linking between abundant cysteine residues of hair keratins. These structures in KAPs are extremely resistant to physicochemical and biochemical modifications. In the living organisms such structures are filled with other biological substances, including keratin proteins, that can be removed by enzymatic digestion. Residual microscaffolds could be applied for a number of applications in medicine and cosmetics, including 3D tissue harvesting or as carriers of biological bioactive substances in medicine or cosmetology. The examples of already applied KAPs will be presented.

 

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Related papers

Presentation: Oral at VII Multidyscyplinarna Konferencja Nauki o Leku, by Andrzej W. Lipkowski
See On-line Journal of VII Multidyscyplinarna Konferencja Nauki o Leku

Submitted: 2010-03-18 10:12
Revised:   2010-04-05 15:50