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The use of magnetic nanoparticles as an effective separator and diagnostic of Candida albicans. |
Katarzyna Niemirowicz 1, Urszula Surel 1, Izabela Święcicka 2, Agnieszka Z. Wilczewska 3, Karolina H. Markiewicz 3, Alina Kułakowska 4, Zbigniew Namiot 5, Beata Szynaka 6, Halina Car 7, Robert Bucki 1,8 |
1. Medical University of Bialystok, Department of Microbiological and Nanobiomedical Engineering (UMB), Mickiewicza 2C, Białystok 15-222, Poland |
Abstract |
Severe fungal infections have significantly contributed to the increasing morbidity and mortality of immunocompromised patients in need of broad-spectrum antibiotic therapy. Therefore, the increasing number of resistant fungal infections creates a constant need for the development of new therapeutic and diagnostic methods. In this study, we show that iron oxide magnetic nanoparticles and their core-shell derivatives possess high affinity to membrane of fungal cells. Additionally, we provide evidence that these nanostructures offer an opportunity to quickly capture, eliminate, and detect presence of Candida albicans as well as to separate these pathogens from different body fluids. This work was financially supported by the National Science Centre, Poland, Grants UMO-2012/05/N/NZ7/00534 (to KN.), UMO-2012/07/B/NZ6/03504 (to RB.) |
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Presentation: Oral at Nano PL 2014, Symposium B, by Katarzyna NiemirowiczSee On-line Journal of Nano PL 2014 Submitted: 2014-06-28 03:42 Revised: 2014-09-26 17:37 |