The rapid development of nanotechnology in the past decade is rising hope that different emerge health problem that human face today, such as increasing number of bacterial resistant infections might be solve with nanostructure designed at atomic level. Iron oxide magnetic nanoparticles and their ceragenins-shell derivatives (MNP-CSA-13) represent one example of such material that despite its small size has the ability to recognize and kill different pathogenic bacteria strains. In this study, we provide evidence that MNP-CSA-13 nanosystem is stable in different body fluids and might be use to elimante multidrug resistant clinical strains of Pseudomonas aeruginosa. Additionaly, the bactericidal activity of MNP or MNP-CSA13 is associated with ability to prevent bacteria biofilm formation. Covalent attachment of CSA-13 to the MNP surface increases its biocompatibility by reducing its otherwise relatively high toxicity towards host cells. MNP and their ceragenins-shell derivatives represent a great promise in developing new methods to fight bacterial infections.

This work was financially supported by the National Science Centre, Poland, Grants , UMO-2012/07/B/NZ6/03504 (to RB.) and UMO-2012/05/N/NZ7/00534 (to KN.)

1. CV: Note about author(s): Robert Bucki, Katarzyna Niemirowicz, Urszula Surel, Paul Savage, PDF document, version 1.5, 0.2MB

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