It is well known that fluorides even at a low concentration but with long time exposure accumulate in the body and lead to numerous metabolic disorders.  Many authors described influence of fluorides on amount and activity of various enzymes taking part in different metabolic ducts. But there are only few articles about influence of fluorides on glycogen metabolism in the muscle, which is very important source of glucose and then energy to muscle work. That fore we decided to examine the energy synthesis in skeletal muscle after fluoride addition. We used skeletal muscle cells from cell line CCL136, which were incubated for 48 hr with 1, 3, 6, and 10 μM NaF and used for measurement of ATP synthesis, glycogen accumulation in the cells and expression of enzymes taking part in glycogen metabolism.

Incubation of skeletal muscle cells with NaF caused increased accumulation of glycogen in skeletal muscle cells, what may suggest that activity of glycogen fosforylase is decreased, what was confirmed in our study by measurement of expression of glycogen fosforylase, enzyme taking part in glucose release from glycogen.. Inhibition the process of glucose releasing from muscle magazines caused decreasing in amount of synthesized cellular ATP.

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