Introduction: In many countries treatment of obesity becomes significant problem. Increasing number of patients with obesity, especially with visceral type of obesity is connected with the increased number of obesity complications. In order to fulfill the market demand of the slimming diet supplements, the number of diet supplements supporting weight loss increased by increasing the content of fat tissue increased. Since the conjucated linoleic acid (CLA) role in the weight loss has been documented, the main ingredients of those products are conjugated linoleic acids (CLA). CLAs containing diet supplements are usually a mixture of two linoleic acid isomers: trans-10 cis-12 CLA and cis-9, trans-11 CLA, contained in equal proportion 1:1. Each of the isomers can exert an opposite biological action in many aspects. But only the trans-10, cis-12 CLA acts as the factor implicated in the adipocites delipidation process in vivo, leading to the fat tissue reduction. The second isomer cis-9, trans-11 does not exert delipidation effect bothin vitro and in vivo.

Aim of work: The actual influence of CLAs on body mass reduction has not been clearly explained. There are still missing data in medical studies concerning the CLAs influence on the micro- and macroelements metabolism in various tissues.  That fore we decided to examine influence of conjugated dienes of linoleic acid (CLA) on fluoride accumulation in hard tissues of mice.

Material and method: In the research we used hard tissues (bones and teeth) and serum of 6 weeks old mice, which were feeding using MURIGRAN fodder including 6.5% of soy olive (control group) or 5.5% of soy olive with 1% CLA supplementation (examined groups: cis-9, trans-11 CLA; trans-10, cis-12 CLA; CLA mix 1:1; LA) during four weeks. Fluoride concentration was determined with the ionselective electrode; calcium and magnesium concentrations with the atomic absorption spectrometry. The results of the study were analyzed with Mann-Whitney U test. The significance level was p ≤ 0,05.

Result: Mice supplementation with various isomers of linoleic acid (cis-9, trans-11 CLA, trans-10, cis-12 CLA, CLA mix 1:1, LA) caused changes in bone and teeth mineral composition and the greatest changes were observed in the case of isomer cis-9, trans-11 CLA, which does not exert delipidation effect both in vitro and in vivo but is added to the slimming diet supplements in 1:1 proportion.

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