The aim of this study was to establish if newly synthesized palladium (II) complexes possess anticancer properties. The chemical similarity between palladium and platinum leads to the expectation that related palladium complexes might also be active against some cancers. For instance, low but significant activity of palladium chloride complexes with hydroxypyridines against the ovarian cancer cell lines was found [1]. According to many authors, changing the nature of the ligand donor atom may be beneficial. Twelve complexes were studied in various cancer cell lines originating from blood (CCRF – acute human leukemia) and solid tumors (Mcf7 – human breast cancer). Anticancer activity of palladium (II) complexes was determined by MTT test which evaluate viability of cells after treatment with compounds tested. Cells were incubated with increasing concentrations of palladium (II) complexes for 24, 48 and 72 hours. In order to evaluate relative anticancer activity IC50 (inhibitory concentration which decreases viability of cells to 50%) was calculated if possible. Palladium chloride complexes with substituted pyridines were prepared under argon. A known amount of PdCl2 was placed in a flask equipped with magnetic stirrer and Py or substituted XnPy in acetonitrile were added. Reaction was carried out at room temperature for 24 h. The results obtained for these newly synthesized palladium complexes indicate that their anticancer activity differs with respect to their structure. Both cell lines viability, however, was affected and increasing time of incubation enhanced the cytotoxic effect. Palladium (II) complexes can be considered as substances of anticancer properties and further study on their properties and also synthesis of new derivatives is advisable.

1. Fazlul Hug, Hasan Tayyem, Philip Beale, Jun Qing Yu, J. Inorg. Biochem. 101 (2007) 30-35

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