The present work is finalized to control the biocompatibility of an haemostatic sponge derived from human plasma proteins. The open cellular structure of the new haemostatic sponge is required to obtain a good performance as material absorbing body fluids and promote the coagulation. In addition of this haemostatic properties the material might be soft, insoluble in body fluids, hypoallergic, flexible and sterile. In order to improve the cohesion of protein chains and, consequently, mechanical behaviour of this sponges, when placed on injured tissues, a little amount of glutharaldehyde to the system was added. The final sponges were sterilised with a dose of 25 kGy of Co 60  radiation as suggested by hygienic requirements but, as known, both this treatments may result in a modification of protein structures and, especially aldehydes added to the system, are highly toxic. In order to verify the biocompatibility of the new final compound, an in vitro investigation was carried out using a fibroblast cell culture system. The results of this investigation show the complete biocompatibility of new protein sponges, nevertheless glutharaldehyde addition and Co60  sterilisation. Finally an in vivo coagulation test was performed. Also the results of such investigation show a good haemostatic behaviour of new biomaterial.

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