Surface functionalization of materials by different methods is very often applied to make the surfaces bioactive and biocompatible. In this study the following question is raised: could well established nanotechnology be used to obtain functional nanoparticles and are they able to induce the deposition of osteoconductive hydroxyapatite (HA) ceramic. It is known that nano dimentions and porous structures influence different biological events and thus they can be utilized in the laboratory to create bilogically integrated multifunctional devices (biomaterials and sensors).
In this paper, subsequent physical vapor deposition of SiOx and CdSe at room temperature or thermal Si nanoparticles growth in SiOx thin film was used to modify glass substrates. To test the ability of the as-nanostructured surfaces to induce the deposition of HA, the samples were immersed in a simulated body fluid (SBF) and simultaneously irradiated with a scanning laser beam for 2 min with a special design. The method of laser-liquid-solid interaction (LLSI) has lead to a synergistic effect due to the nanostructured substrate, aqueous solution and laser irradiation. The grown layers were investigated by light microscopy, SEM, EDX, FTIR and Raman spectroscopy. Light microscopy and SEM revealed a white sponge-like layer covering the surfaces and having nanodimentions, with morphology different from that on initial glass surfaces. Raman and FTIR spectroscopies showed the typical vibrational modes of HA. Results from EDX showed higher Ca and P content in the stripes of the laser-substrate interaction, thus indicating the influence of the laser energy.
This paper showed that the applied nanotechnology could be efficiently used for producing functional nanostructures able to induce HA deposition, and that the proposed novel method of LLSI promotes and enhances the HA nucleation in comparison with the traditional methods of prolonged biomimetic soaking in SBF.

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